ID A0A2U4A7H6_TURTR Unreviewed; 910 AA.
AC A0A2U4A7H6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Sorting nexin-25 isoform X7 {ECO:0000313|RefSeq:XP_019776946.2};
GN Name=SNX25 {ECO:0000313|RefSeq:XP_019776946.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019776946.2};
RN [1] {ECO:0000313|RefSeq:XP_019776946.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019776946.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019776946.2; XM_019921387.2.
DR AlphaFoldDB; A0A2U4A7H6; -.
DR Proteomes; UP000245320; Chromosome 21.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06878; PX_SNX25; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037899; SNX25_PX.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 141..307
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 430..544
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 690..810
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 591..639
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 910 AA; 103791 MW; 1DADCEF65C611226 CRC64;
MHPEATDSSG AGLTEAPGER RPDSREDAAA PGGPGGGSWR APVAVAALAA VPLCFLGPGC
WEAGSAGPGT VLLRLSLYLG CAAAAFLLGT LFSLVCRSPR APPPDFAAAW RRLAAAARRP
PESPVCGNSH ESVQSRRVVI SHNMDKALKE VFDYSYRDYI LSWYGSLSRD EGQLYHLLSE
DFWEVVRRLR HRLSRVDMVR VVCSDVVRAL LAHFCDLKAA DARHEEQPRP FVLHAFLRNS
DDEVRFLQTC SRVLVFCLLP SKDVQSLSLR IMLAEILTAK VLKPVVELLS NPDYINQMLL
AQLEHREQVN EHHKRAYTYA PSYEEFIKLI NSNSDVEFLK QLRYQIVVEI IQATTISSFP
QLKRHKGKET AAMKADLLRA RNMKRYINQL TVAKKQCEKR IRILGGPAYD QQEDGPLDEG
EGPQSQKILQ FEDILANASY REHFRTYMER MDKRALISFW ESVEYLKNAH KNEIPQLVGE
IYQNFFVESK EISVEKSLYK EIQQCLVGNK GIEVFCKIQG DVYEMLKDRY YPSFIVSDLY
EKLMIKEEEK HVSQLISNKD EMNPGGEAGE ESVDDGTSRI NEQTSFAVNK LRELNEKLDY
KRQALNSIQN APKPDKKIVS KLKEEIILIE KERTELQLHM ARTDWWCENL GMWKASITSG
EFRQQHHACS PGASLTAHML RESLPSALSV SLVLVEPPFQ VTEENGEQMP CYFVMVSLQE
VGGVETKNWT VPRRLSEFQN LHRKLSECFP SLKKVQLPSL SKLPFKSVDQ KFMEKSKNQL
NKFLQNLLSD ERLCQSEALY AFLSPSPDYL KVIDVQGKKS TFSLSSFLER LPRDFFSHQE
EEAEEDSDLS DSGDDVDGRK DSLAEPCFML IGEIFELRGM FKWVRRTLIA LVQVTFGRTI
NKFFRFSLYF
//
