ID A0A2U4AC19_TURTR Unreviewed; 604 AA.
AC A0A2U4AC19;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Signal transducing adapter molecule 2 isoform X1 {ECO:0000313|RefSeq:XP_019778553.1};
GN Name=STAM2 {ECO:0000313|RefSeq:XP_019778553.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019778553.1};
RN [1] {ECO:0000313|RefSeq:XP_019778553.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019778553.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in intracellular signal transduction mediated by
CC cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it
CC plays a role in signaling leading to DNA synthesis and MYC induction.
CC May also play a role in T-cell development. Involved in down-regulation
CC of receptor tyrosine kinase via multivesicular body (MVBs) when
CC complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds
CC ubiquitin and acts as a sorting machinery that recognizes ubiquitinated
CC receptors and transfers them to further sequential lysosomal
CC sorting/trafficking processes. {ECO:0000256|ARBA:ARBA00043869}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
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DR RefSeq; XP_019778553.1; XM_019922994.2.
DR AlphaFoldDB; A0A2U4AC19; -.
DR STRING; 9739.ENSTTRP00000014767; -.
DR GeneID; 101319805; -.
DR InParanoid; A0A2U4AC19; -.
DR OrthoDB; 620063at2759; -.
DR Proteomes; UP000245320; Chromosome 7.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd21390; GAT_STAM2; 1.
DR CDD; cd11963; SH3_STAM2; 1.
DR CDD; cd16999; VHS_STAM2; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035675; STAM2_SH3.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR047493; VHS_STAM2.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF1; SIGNAL TRANSDUCING ADAPTER MOLECULE 2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00726; UIM; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 94..222
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 280..339
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 411..445
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 587..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 65747 MW; 419619D4676DE856 CRC64;
MPAAGGTSYR EERSGRSARA ERGPGAGPSG RSGAGAVAEV PDATGAEPSR KPGPWVPQPG
AAAEPPPDRS NLGSGAGEMP LFTANHFEQD VEKATNEYNT TEDWSLIMDI CDKVGSTPNG
AKDCLKAIMK RVNHKVPHVA LQALTLLGAC VANCGKIFHL EVCSRDFATE VRAVIKNKAH
PKVCEKLKSL MVEWSEEFQK DPQFSLISAT IKSMKEEGIT FPSAGSQTVS VAAKNGTSLN
KNKEDEDIAK AIELSLQEQK QQHTETKSLY PSAEIPSNNK VARKVRALYD FEAVEDNELT
FKHGEIIIVL DDSDANWWKG ENHRGIGLFP SNFVTTNLNI EPEAAAVDKL NVIDDEEEEI
KKSEPEPVYI DEDKMDRALQ VLQSIDPTDS KPDSQDLLDL EDICQRMGPM IDEKLEEIDR
KHSELSELNV KVLEALELYN KLMNEAPVYS VYSKIHHPAH YPPSSAGVPM QTYPVQPHGA
NYMGQSIHQV TVAQSYSLGP DQIGPLRSLP PNVNSSVTTQ PAPTPYLSAG QDTVSNPTYM
NQNSHLQSAT GAAAYTQQMG MSVDLSSHQS TTSSLPRSAG FAVAAPAHSV SQQQTDYPQQ
QPLL
//
