ID A0A2U4AFD2_TURTR Unreviewed; 2020 AA.
AC A0A2U4AFD2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Fanconi anemia group M protein isoform X3 {ECO:0000313|RefSeq:XP_019779519.1};
GN Name=FANCM {ECO:0000313|RefSeq:XP_019779519.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019779519.1};
RN [1] {ECO:0000313|RefSeq:XP_019779519.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019779519.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC FANCM sub-subfamily. {ECO:0000256|ARBA:ARBA00009889}.
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DR RefSeq; XP_019779519.1; XM_019923960.2.
DR GeneID; 101335644; -.
DR OrthoDB; 12149at2759; -.
DR Proteomes; UP000245320; Chromosome 2.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd18033; DEXDc_FANCM; 1.
DR CDD; cd12091; FANCM_ID; 1.
DR CDD; cd18801; SF2_C_FANCM_Hef; 1.
DR CDD; cd20077; XPF_nuclease_FANCM; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.20.1320.20; hef helicase domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR031879; FANCM-MHF-bd.
DR InterPro; IPR039686; FANCM/Mph1-like_ID.
DR InterPro; IPR044749; FANCM_DEXDc.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR047418; XPF_nuclease_FANCM.
DR PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF02732; ERCC4; 1.
DR Pfam; PF16783; FANCM-MHF_bd; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00891; ERCC4; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 107..275
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 461..636
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1645..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1431..1449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1510
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2020 AA; 228438 MW; EFE7502E8D66D637 CRC64;
MSRRQRTLFQ TWGSRVSRST GAPSCSSGTE RPQSPGISGA SFPAAAQAAE AAEAAEAQPE
SDDDVLLVAV YEAERQLSLE NGGFCTSAGA LWIYPTNCPV RDYQLHIART ALFCNTLVCL
PTGLGKTFIA AVVMYNFYRW FPSGKIVFMA PTKPLVTQQI EACYRVMGIP QSHMAEMTGC
TQAFTRKEIW GSKRVHFLTP QVMVNDLSRG ACPAAEIKCL VIDEAHKALG NYAYCQVVRE
LVKYTNHFRI LALSATPGSD IKAVQQVITN LLIGQIEIRS EDSPDILPYS HERRVEKLVV
PLGEELGAIQ KAYIQILEAL ASSLIRRNVL MRRDIPNLTK YQIILARDQF RKNPSPNIVG
LQQGIIEGEF AICISLYHGY ELLQQMGMRS LYFFLCGIMD GTKGMTRAKK ELSRNEDFMK
LYNHLECMFA HTRSTSASGI SAIKKGDEDK KFCYSHPKLK KLEEIVVEHF KSWNAQKTSD
KKCDETRVMI FSSFRDSVQE IAEMLLQHQP IIRVMTFVGH ASGKSMKGFT QKEQLEVVKQ
FRSGGYNTLV STCVGEEGLD IGEVDLIICF DAQKSPIRLV QRMGRTGRKR QGRIVVILAE
GREERTYNQS QCNKRSIYKA ISGNRQVLHF YQGSPRMVPD GINPHLHKMF ITHGVYEPDK
PSRNLQRKSS IFSYRKGMRQ SNSKNDWFLS EEEFKLWNRR YRLRDTDEIK EITLPQVQFL
SLQNEENRPT QEPTTGIHQL SLSEWRLWQD HPLPTYQVDH SDRCHHFVNI MQMIEGMRHE
EGECSYELEI KSYLQTEDVS STSSAPRNEY NPFANGIFTS NKKSSFTKNI NQGKSLSITE
SDEECAEIFK QIRIKPTEIA SLKRKASKEL KKDQPKKEHK EVVMGPLDTD GSSTAKNIFQ
VDLLNDKRVS DTDEVAATCA ISENVGNRSC GLLADCQFTN KSTSSFTGKF LDSGYNSFSD
EKSLSSSLFF PFEDELYIAR TDDKFYNCHS LTKEVLANVE RFLSHSPPPL SALSNLEYEI
SKGSALENLL FVPYTECLQN DKSTCLMSHS TINSQQNLEL SSLKFITHPS EKSCLYGTIN
DKISAEPSFC YYNKVHKDIK NEHLVSNHHI QINTGPPKYF VEEKNHDVDN SGLPILHTDQ
DESLLLFEDV NTECNDVNLP PLNSKCKSLC VSDKTALSEM ALGSQFLISD ELLLGNNSEP
QDQIIGDTNS WKSHEDLRGV HEEKLKNDEY GFDCSKDLFS VTFDLGFCSP DTDDEILEHA
SDTNKNKILD DLSGGCLDIK EINDANYVSN QAVISRDHVD SSTSETITNP SSEDKRSPTF
ACFPMNATKN KEFMSPGYSQ FSLPVREKVM STPLSQSNTA NLFSKKRIEM ARKSDSNKGK
INLQSFKETL NSTFDDLGLS IEKANSREQI NLHQSCHSAK VLDEQLTSSE SEDDEIFRRK
SKKTKGNVLE SPENQKNSEV DSPLHAVKKR RVPPNRLVAR KFLDDEAELS QEDAECVSSD
ENDESENEQD SSLLDFLNDE TQLSQAINDS EMRAIYMKSV RSPLMNNRYK MVHKKHNNIN
IFSQIPEQDE TYLEDSFCVD EEESCKSQSS EEVCVDFNLI TEDCFASRSK KYKTRRAVKL
KQMKMRQNCA SSKKKLCRII LPDDSSEEEN DVNDKQESST VINPSAVTKS EQQNHCLNLV
PSGSSLQSRD HSNPVVNQSP NQRQQTPLNL KVTVSDVSDF KPQSRTKIEP TSSSFTTVDS
QKDCRKFPIQ LKDTSALEDS GTSVAYCSNS RPRLAGTHAS LRLPQEGQRT CILVDSREIT
SGSEVISSLR AVHGLQVEVC PLNGCDYIVS NRMVVERRSQ SEMLNSTNKN KLIEQIQYLQ
SMFERICVIV EKDREKTGDT SRMFRRTKSY DSLLTTLTGA GIRILFSSCQ EETADLLKEL
SLVEQRKNVG IHVSTVVNSN KCEALQFYLS IPNISYIAAL NMCHQFSSVK KMTNSSPQEI
SMYAQVTHQK AEEIYRYIHY IFDMQMLPND LNKGSFKSDA
//
