ID   A0A2U4AR91_TURTR        Unreviewed;       609 AA.
AC   A0A2U4AR91;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X2 {ECO:0000313|RefSeq:XP_019783334.2};
GN   Name=PAPSS1 {ECO:0000313|RefSeq:XP_019783334.2};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019783334.2};
RN   [1] {ECO:0000313|RefSeq:XP_019783334.2}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019783334.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Sulfur metabolism; sulfate assimilation.
CC       {ECO:0000256|ARBA:ARBA00005050}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the sulfate
CC       adenylyltransferase family. {ECO:0000256|ARBA:ARBA00009290}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the APS kinase
CC       family. {ECO:0000256|ARBA:ARBA00007268}.
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DR   RefSeq; XP_019783334.2; XM_019927775.2.
DR   AlphaFoldDB; A0A2U4AR91; -.
DR   UniPathway; UPA00097; -.
DR   Proteomes; UP000245320; Chromosome 5.
DR   GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004781; F:sulfate adenylyltransferase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000103; P:sulfate assimilation; IEA:UniProtKB-UniPathway.
DR   CDD; cd02027; APSK; 1.
DR   CDD; cd00517; ATPS; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.10.400.10; Sulfate adenylyltransferase; 1.
DR   HAMAP; MF_00065; Adenylyl_sulf_kinase; 1.
DR   InterPro; IPR002891; APS_kinase.
DR   InterPro; IPR025980; ATP-Sase_PUA-like_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR024951; Sulfurylase_cat_dom.
DR   InterPro; IPR002650; Sulphate_adenylyltransferase.
DR   NCBIfam; TIGR00455; apsK; 1.
DR   NCBIfam; TIGR00339; sopT; 1.
DR   PANTHER; PTHR11055; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE; 1.
DR   PANTHER; PTHR11055:SF17; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1; 1.
DR   Pfam; PF01583; APS_kinase; 1.
DR   Pfam; PF01747; ATP-sulfurylase; 1.
DR   Pfam; PF14306; PUA_2; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          218..370
FT                   /note="ATP-sulfurylase PUA-like"
FT                   /evidence="ECO:0000259|Pfam:PF14306"
FT   DOMAIN          379..602
FT                   /note="Sulphate adenylyltransferase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01747"
SQ   SEQUENCE   609 AA;  69084 MW;  0DCE62C5A460711A CRC64;
     MSPSQGMQRA TNVTYQAHHV SRNKRGQVVG TRGGFRGCTV WLTGLSGAGK TTVSMALEEY
     LVCHGIPCYT LDGDNIRQGL NKNLGFSPED REENVRRIAE VAKLFADAGL VCITSFISPY
     TQDRNNARQI HEGASLPFFE VFVDAPLHVC EQRDVKGLYK KARAGEIKGF TGIDSEYEKP
     EAPELVLKTD SCDVNDCVQQ VVELLQERDI VPVDASYEVK ELYVPENKLH LAKTDAETLP
     ALKISKVDMQ WVQVLAEGWA TPLNGFMRER EYLQCLHFDC LLDGGVINLS VPIVLTATQE
     DKERLDGCTA FALMYEGRRV AILRNPEFFE HRKEERCARQ WGTTCKNHPY IKMVMEQGDW
     LIGGDLQVLD RIYWNDGLDQ YRLTPTELKQ KFKDMNADAV FAFQLRNPVH NGHALLMQDT
     HKQLLERGYR RPVLLLHPLG GWTKDDDVPL MWRMKQHAAV LEEGILNPET TVVAIFPSPM
     MYAGPTEVQW HCRARMVAGA NFYIVGRDPA GMPHPETGEG LYEPTHGAKV LTMAPGLITL
     EIVPFRVAAY NKKKKRMDYY DAEHHEDFEF ISGTRMRKLA REGQKPPEGF MAPKAWTVLM
     EYYKSLEKA
//