ID A0A2U4ARR8_TURTR Unreviewed; 981 AA.
AC A0A2U4ARR8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ubiquitin-like modifier-activating enzyme 6 isoform X3 {ECO:0000313|RefSeq:XP_019783658.1};
GN Name=UBA6 {ECO:0000313|RefSeq:XP_019783658.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019783658.1};
RN [1] {ECO:0000313|RefSeq:XP_019783658.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019783658.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR RefSeq; XP_019783658.1; XM_019928099.2.
DR AlphaFoldDB; A0A2U4ARR8; -.
DR GeneID; 101333425; -.
DR OrthoDB; 20494at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000245320; Chromosome 5.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd01490; Ube1_repeat2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR032420; E1_4HB.
DR InterPro; IPR032418; E1_FCCH.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF186; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6; 1.
DR Pfam; PF16191; E1_4HB; 1.
DR Pfam; PF16190; E1_FCCH; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 2.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 850..972
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
SQ SEQUENCE 981 AA; 110880 MW; E46EE4C125169550 CRC64;
MMHYTAKNLV LAGIKALTIH DTEECQAWDL GTNFFLCEDD VVSMRNRAEA VLQRIAELNP
YVHVTSSSIP LNETTDLSFL HRYQCVVLTE IKLSLQKKIN DFCRSQCPPV KFISADIHGI
WSRLFCDFGD EFEVLDTTGE EPKEIFISNI TQANPGIVTC LENHPHKLET GQFLTFREIN
GMTGLNGSTQ QITVVSPFSF SIGDTRELEP YLHGGIAVQV KTPKTFCFEP LEKQIKHPKC
LIADFSKPEA PLEIHSAMLA LDQFQENYSR KPNTGCQQDS EELLKLATSI SETLEEQPEV
NYDIVRWLSW TAQGFLPPLA AAVGGVASQE VLKAVTGKFS PLCQWLYIEA ADIVESLGKP
EREEFLPRGD RYDALRACIG DTLCRKLQNL NIFLVGCGAI GCEMLKNFAL LGVGTGKEKG
MVTVTDPDLI EKSNLNRQFL FRPHHIQKPK SYTAADATLK INPQLKIDAH LNKVCPATEV
IYNDEFYTKQ DIIITALDNV EARRYVDSRC LANLRPLLDS GTMGTKGHTE VIVPHLTESY
NSHRDPPEEE IPFCTLKSFP AAIEHTIQWA RDKFESSFSY KPSLFNKFWQ TYPSAEEVLK
KIQTGQSLEG CFQVIKLLSR RPRNWSHCVE LARLKFEKYF NHKALQLLHC FPLDTRLKDG
SLFWQSPKRP PSPLKFDLNE PLHFSFLLNA AKLYATVYCI PFTEEDLSAD TLLNILSEVK
IQEFRPSNKV VQTDETARKP DHVPVSSEDE RNAVFQLEKA ISSSEATTSD LQMAVLSFEK
DDDRNGHIDF ITAASNLRAK MYSIEPADRL KTKRIAGRII PAIATSTAAV TGLVALEMIK
VAGDYPFEAY KNCFFNLAIP IIVFTETSEV RKTEIRNGIS FTIWDRWIIH GKEEFTLLDF
INAVKEKYGI EPTMVVQGVK MLYVPVMPGH AKRLKLTMHK LVKPSTEKKY VDLTVSFAPD
TDGDEDLPGP PVRYYFSHDT D
//
