ID   A0A2U4AS58_TURTR        Unreviewed;       846 AA.
AC   A0A2U4AS58;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Aryl hydrocarbon receptor {ECO:0000256|ARBA:ARBA00015909};
GN   Name=AHR {ECO:0000313|RefSeq:XP_019783807.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019783807.1};
RN   [1] {ECO:0000313|RefSeq:XP_019783807.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019783807.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_019783807.1; XM_019928248.2.
DR   AlphaFoldDB; A0A2U4AS58; -.
DR   STRING; 9739.ENSTTRP00000006540; -.
DR   GeneID; 101329569; -.
DR   InParanoid; A0A2U4AS58; -.
DR   OrthoDB; 5360131at2759; -.
DR   Proteomes; UP000245320; Chromosome 9.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:UniProt.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:1904613; P:cellular response to 2,3,7,8-tetrachlorodibenzodioxine; IEA:UniProt.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR   CDD; cd11436; bHLH-PAS_AhR; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR039091; AHR/AHRR.
DR   InterPro; IPR033348; AHR_bHLH.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR   PANTHER; PTHR10649:SF9; ARYL HYDROCARBON RECEPTOR; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW   Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Receptor {ECO:0000313|RefSeq:XP_019783807.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   DOMAIN          27..80
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          110..180
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          429..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          821..846
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   846 AA;  95573 MW;  88D954D41188646D CRC64;
     MNSSSANITY ASRKRRKPVQ KTVKPVPAEG IKSNPSKRHR DRLNTELDRL ASLLPFPQDV
     VNKLDKLSVL RLSVSYLRAK SFFDVALKST PADRNGVQDN CRTKFREGLN LQEGEFLLQA
     LNGFVLVVTT DALVFYASST IQDYLGFQQS DVIHQSVYEL IHTEDRAEFQ RQLHWALNPS
     QCPDSGQKMD EANGLSQPAV YYNPDQVPPE NSSSMERCFV CRLRCLLDNS SGFLAMNFQG
     RLKYLHGQNK KGKDGSILPP QLALFAIATP LQPPSILEIR TKNFIFRTKH KLDFTPTGCD
     AKGRIVLGYT EAELCMRGSG YQFIHAADML YCAEYHIRMI KTGESGMIVF RLLTKDNRWT
     WVQSNARLVY KNGRPDYIIA TQRPLTDEEG TEHLRKRNLK LPFMFTTGEA VLYEVTNPFP
     PIMDPLPIRT KNGAGGKDSA TKSALSKDSL NPSSLLNAMM QQDESIYRYP ASSSTPFERN
     FFNDSQNECS NWQNNVAPVG SDNILKHEQI GQSQEMNPTL SGDHAGLFPD NRNSDLYSIM
     KHLGIDFEDI KHMQQNEEFF RTDFSGEEDF RDIDLTDEIL TYVEDSLNKS ALGCSGYHQQ
     QSMALNPSCM VQEHLQLEQQ EQLQQHQKHR AVEQQQQLCQ KMQHMQVNGM FANWNSNQSV
     PFNCPQQDLQ QYNVFSDVPG TSQELPYKSE IDTMPYAQNF IPCGQSVLPP HSKGTQLDFP
     IGDFEPAPYP TTSSNLEDFV TCLQVPQSQR HGLNPQSAIV TPETCYAGAV SMYQCQPEAQ
     HSHVAQMQYN PTMPGPQAFL NKFQNGGVLN ETYPAELNSI NNTQPTTHLH PSEARPFSDL
     TSSGFL
//