ID A0A2U4ASH0_TURTR Unreviewed; 811 AA.
AC A0A2U4ASH0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Toll-like receptor 10 {ECO:0000313|RefSeq:XP_019783908.1, ECO:0000313|RefSeq:XP_033712815.1};
GN Name=TLR10 {ECO:0000313|RefSeq:XP_019783908.1,
GN ECO:0000313|RefSeq:XP_033712815.1, ECO:0000313|RefSeq:XP_033712816.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019783908.1};
RN [1] {ECO:0000313|RefSeq:XP_019783908.1, ECO:0000313|RefSeq:XP_033712815.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019783908.1,
RC ECO:0000313|RefSeq:XP_033712815.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_019783908.1; XM_019928349.2.
DR RefSeq; XP_033712815.1; XM_033856924.1.
DR RefSeq; XP_033712816.1; XM_033856925.1.
DR GeneID; 101319483; -.
DR OrthoDB; 21383at2759; -.
DR Proteomes; UP000245320; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF23; TOLL-LIKE RECEPTOR 10; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 576..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 632..775
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 811 AA; 94244 MW; F1C3F1BF957D8815 CRC64;
MKQIRSIYVF CSIVTSVHSG ASKLPEETEL TTNCSNASLR KVPEDLTPTT TVLDLSYNLL
FQLQRSDFHS LSKLKVLILC HNRIQELDIK TFEFNKELSY LDVSYNRLKS VTWFSLAGLR
HLDLSFNDFD TVPTCEETGN MSHLEILGLS GAKIQKSDFQ KIAHLHLNTV FLGLRTLSHY
EEGSLPILNT TKLHIVLPMN TNFWVLLRDG MKTSKILEIT NIDGKSQFAS YETQQNLILE
NAKTSILLLN KVDLLWDDLL LIFQFVWHTS VEYFQIQHVT FGGKVYLDHN SFDYSNTVMR
TIKLENVHFR IFNIPQERVY LLFTKMDIEN LTISDAQMPH MLFPIYPTRF QYLNFANNIL
TDDVFKTSIQ LPHLKTLILK DNKLETLSLV SCFAGNTSLR HLDLSENLLQ HENDENCLWP
ETLITMNLSS NKFADSVFRC LPRNIQILDL NNNKIQTVPK DIIHLTSLRE LNLAFNFLTD
LPGCSHFRRL SVLNVEMNLI LSPSLEFFQS CQEVKTLNVG RNPFRCTCEL RDFIQLEKYS
EGMMVGWSDS YICEYPLNLK GTQLKDVRLP EISCNAALLI VTIVVIMLVL GTAVAFCCLH
FDLPWYLRML GQWTQTWHRV RKTSQEQLKR NIQFHVFISY SEHDSAWVKY ELIPNIEKED
SSVLICLHEG NSDPGKSITE DTINCIEKSY KCIFVLSPNF VQTEWCHYER YFAHHNLFRE
SSDYIMLILL EPIPLYCIPP RYPKLKTLME KKAYLEWPKD RRKCGLFWAN LRAAIRVNLL
KTREMCELQT FTELNEESRG SAISLIRTDC L
//
