ID A0A2U4AV25_TURTR Unreviewed; 484 AA.
AC A0A2U4AV25;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Lysosomal cobalamin transport escort protein LMBD1 {ECO:0000256|ARBA:ARBA00039618};
DE AltName: Full=LMBR1 domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042599};
GN Name=LMBRD1 {ECO:0000313|RefSeq:XP_019784820.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019784820.1};
RN [1] {ECO:0000313|RefSeq:XP_019784820.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019784820.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
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DR RefSeq; XP_019784820.1; XM_019929261.2.
DR AlphaFoldDB; A0A2U4AV25; -.
DR GeneID; 101321894; -.
DR OrthoDB; 8533at2759; -.
DR Proteomes; UP000245320; Chromosome 12.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Developmental protein {ECO:0000256|ARBA:ARBA00023218};
KW Gastrulation {ECO:0000256|ARBA:ARBA00023218};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 484 AA; 55094 MW; 3951BD23955C4BB2 CRC64;
MAAAAGAASA ELVIGWCIFG LLLLAILAFC WVYVRKYQSQ RESEVVSTIT AIFSLAIALI
TSALLPVDIF LVSYMKNQNG TFKDWANANV SRRIEDTVLY GYYTLYSVIL FCVFFWIPFV
YFYYEEKDDD DTGKCTQIKT AFKYTFGFAV ICALLLLVGA FVPLNLPDNK NSTEWEKVKF
LFEELGSSHG LAALSFSISS LTLIGMLAAI IYTAYGMSAL PLNLIKGTRS AAYERLENTE
DIEEVEQHIQ TIKSKSKDGR PLPARDKHAL KQLEERLRTL RKRERHLEFI ENSWWTKFCG
ALRPLKIIWG IFFILVALLF IISLFLSNLD KALHSAGIDS GFIIFGANLS NPLNMLLPLL
QTVFPLDYIL ITTIIMYFIF TSMAGIRNIG IWFFWIRLYK IRRGRTRPQA LLFLCMILLL
IVLHTSYMIY SLAPQYVMYG SQNYLIESNI TYDAHKGNST LSVPKRCDAD APEGVRDWVD
CLLL
//
