ID   A0A2U4AVF7_TURTR        Unreviewed;       945 AA.
AC   A0A2U4AVF7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Sorting nexin-14 isoform X2 {ECO:0000313|RefSeq:XP_019784943.1};
GN   Name=SNX14 {ECO:0000313|RefSeq:XP_019784943.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019784943.1};
RN   [1] {ECO:0000313|RefSeq:XP_019784943.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019784943.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   RefSeq; XP_019784943.1; XM_019929384.2.
DR   AlphaFoldDB; A0A2U4AVF7; -.
DR   GeneID; 101325850; -.
DR   OrthoDB; 2877434at2759; -.
DR   Proteomes; UP000245320; Chromosome 12.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          130..303
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          335..467
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          569..689
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   945 AA;  110082 MW;  7A719639EC63C420 CRC64;
     MAPWVRTLGE KLKQRLRLDV GREICRQYPM FCFLLLCLSA ASLLLNRYLH VLMIFWSFVA
     GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGRS CAVCGKVKCK RHRPALLLEN
     YQPWLDLKIS SKVDASLSEV LELVLENFIY PWYRDVTDDE SFVDELRIIL RFFASVLIRR
     IHKVDIPSII TKKLLKAAMK HIEVIVKASQ KENTEFLQQA ALEEYGPELH VALRSRRDEL
     HYLRKLTELL FPYILPPKAT DCRSLTLLLR EILSGSVFLP SLDFLADPDT VNHLLIIFID
     DSPPEKATEP PSPLVPFLQK FAEPRNKKPS VLKLELKQIR EQQDLLFRFM NFLKQEGAVH
     VLQICLTVEE FNDRILRPEL SNDEMLSLHE ELQKIYKTYC LDESIDKIRF DPFIVEEIQK
     IAEGPYIDVV KLQTMRCLFE AYEHVLSLLE NVFTPMFCHS DEYFRQLLRG AESPTRNSKL
     NRSSLSLDDF RSTQKRGESF GISRIGSKIK GVFKSTTMEG AMLPNYGLAE GEDDFIEEGI
     VVMEDDSPVE AVNTPNTPRN LAAWKISIPY VDFFEDTSSE RKEKKERIPV FCIDVERNDR
     RAVGHEPEHW SVYRRYLEFY VLESKLTEFH GTFPDAQLPS KRIIGPKNYE FLKSKREEFQ
     EYLQKLLQHP ELSNSQLLAD FLSPNGGETQ FLDKILPDVN LGKIIKSVPG KLIKEKGQHL
     EPFIMNFINS CESPKPKPSK PELTILSPTS ENNKKLFNDL FKNNANRAEN TERKQNQNYF
     MEMMTLEGVY DYLMYVGRVV FQVPDWLHHL LMGTRILFKN TLEMYTDYYL HCKLEQLFQE
     HRLVSLITLL RDAVFCENTE PRSLQDKQKR AKQTFEEMMN YIPDLIVKCI GEEAKYESIR
     LLFDGLQQPV LNKQLTYVLL DIVIQELFPE LSKVQKEVTS VTSWM
//