ID   A0A2U4AVH9_TURTR        Unreviewed;       906 AA.
AC   A0A2U4AVH9;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Sorting nexin-14 isoform X7 {ECO:0000313|RefSeq:XP_019784946.1};
GN   Name=SNX14 {ECO:0000313|RefSeq:XP_019784946.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019784946.1};
RN   [1] {ECO:0000313|RefSeq:XP_019784946.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019784946.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_019784946.1; XM_019929387.2.
DR   AlphaFoldDB; A0A2U4AVH9; -.
DR   GeneID; 101325850; -.
DR   OrthoDB; 2877434at2759; -.
DR   Proteomes; UP000245320; Chromosome 12.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          130..304
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          336..468
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          570..690
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   906 AA;  105689 MW;  8080E2CF1662E452 CRC64;
     MAPWVRTLGE KLKQRLRLDV GREICRQYPM FCFLLLCLSA ASLLLNRYLH VLMIFWSFVA
     GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGRS CAVCGKVKCK RHRPALLLEN
     YQPWLDLKIS SKVDASLSEV LELVLENFIY PWYRDVTDDE SFVDELRIIL RFFASVLIRR
     IHKVDIPSII TKKLLKAAMK HIEVIVKASQ KVENTEFLQQ AALEEYGPEL HVALRSRRDE
     LHYLRKLTEL LFPYILPPKA TDCRSLTLLL REILSGSVFL PSLDFLADPD TVNHLLIIFI
     DDSPPEKATE PPSPLVPFLQ KFAEPRNKKP SVLKLELKQI REQQDLLFRF MNFLKQEGAV
     HVLQICLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY CLDESIDKIR FDPFIVEEIQ
     KIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH SDEYFRQLLR GAESPTRNSK
     LNRSSLSLDD FRSTQKRGES FGISRIGSKI KGVFKSTTME GAMLPNYGLA EGEDDFIEEG
     IVVMEDDSPV EAVNTPNTPR NLAAWKISIP YVDFFEDTSS ERKEKKERIP VFCIDVERND
     RRAVGHEPEH WSVYRRYLEF YVLESKLTEF HGTFPDAQLP SKRIIGPKNY EFLKSKREEF
     QEYLQKLLQH PELSNSQLLA DFLSPNGGET QFLDKILPDV NLGKIIKSVP GKLIKELFND
     LFKNNANRAE NTERKQNQNY FMEMMTLEGV YDYLMYVGRV VFQVPDWLHH LLMGTRILFK
     NTLEMYTDYY LHCKLEQLFQ EHRLVSLITL LRDAVFCENT EPRSLQDKQK RAKQTFEEMM
     NYIPDLIVKC IGEEAKYESI RLLFDGLQQP VLNKQLTYVL LDIVIQELFP ELSKVQKEVT
     SVTSWM
//