ID A0A2U4AWG0_TURTR Unreviewed; 1133 AA.
AC A0A2U4AWG0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=DNA mismatch repair protein Msh3 isoform X2 {ECO:0000313|RefSeq:XP_019785310.1};
GN Name=MSH3 {ECO:0000313|RefSeq:XP_019785310.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019785310.1};
RN [1] {ECO:0000313|RefSeq:XP_019785310.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019785310.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
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DR RefSeq; XP_019785310.1; XM_019929751.2.
DR AlphaFoldDB; A0A2U4AWG0; -.
DR GeneID; 101328726; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000245320; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 967..983
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 709..736
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 24..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 126911 MW; 594E4E31BF348CA6 CRC64;
MSRRKPVSGG AAPAGPGPAR QAVLSRFFQS TGSLKSTSSA TGTAEKADPD SDSAAPLAAT
LPPQLPPHVV GSVQGGAGPS VAEIDRSKKR PLESDGPVKK KAKKVQEKEE GSDSVMSGNA
EPKKHLRTRI VLKSLEKLKE FCCDSALPQN RVQTESLQKR FAVLPKCTDF DDIDLLRAKN
AVSSEDSKSQ TSQKDKTLSH CGSSHSSCEN LQKTSDSKPS NKRTKSIYTP LELQYIEMKQ
QQKDAILCVE CGYKYRFFGE DAEIAARELN IYCHLDHNFM TASIPTHRLF VHVRRLVAKG
YKVGVVKQTE TAALKAIGDS KSSLFSRKLT ALYTKSTLIG EDVNPLVKLD DAVNVDEIMT
DTSTSYLLCI CENKENVKDK KKGNVFIGLV GVQPTTGEVV FDSFQDSASR SELETRILCL
QPVELLLPSD LSEQTEMLIH RTTAVSMRDD RIRVERMDNM YFEYSHAFQE VTEFYAKDIV
DGSQSFSGII NLEKPVICSL AAIIRYLKEF NLEKVLSKPK NFKQLSGEME FMTINGTTLR
NLEILQNQTD MKTKGSLFWV LDHTKTSFGR RKLKKWVTQP LLKLREINAR LDAVSEVLHS
ESSVFGQIEN HLRKLPDIER GLCSIYHKKC STQEFFLIVK TLYHLKSEFQ ALIPAVNSHV
QSELLQTFIS EIPELLSPVE HYLKILNEQA AKIGDKTELF KDLSHFPLIK KRKDEIQEVT
DKIQTHLQEI RKILKNPSAQ YVTVSGQEFM IEVKNSAVSC IPTDWVKVGS TKAVSRFHSP
FIVENYRHLN QLREQLVLDC SAEWLDFLEN FSEHYHSLCK AVHHLATVDC IFSLAKVAKQ
GDYCRPTLQE ERKIIIKNGR HPVIDVLLGE QGQYVPNSTN LLGDSERVMI ITGPNMGGKS
SYIKQVALIT IMAQIGSYVP AEEATVGIVD GIFTRMGAAD NICKGQSTFM EELADTAEII
RKATSQSLVI LDELGRGTST HDGIAIAYAT LEHFIRDVKS LTLFVTHYPP VCELEKSYSQ
QVGNYHMGFL VNEDESKQDP GEEDQVPDFV TFLYQITRGV AARSYGLNVA KLADVPGEIL
KKAASKSKEL EGLVNMKRKR LKCFAKLWTI NDANDLQKWM DEFKLEEITD CSS
//
