ID   A0A2U4B1I6_TURTR        Unreviewed;       744 AA.
AC   A0A2U4B1I6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=PMS1 protein homolog 1 isoform X4 {ECO:0000313|RefSeq:XP_019787083.1};
GN   Name=PMS1 {ECO:0000313|RefSeq:XP_019787083.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019787083.1};
RN   [1] {ECO:0000313|RefSeq:XP_019787083.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019787083.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_019787083.1; XM_019931524.2.
DR   AlphaFoldDB; A0A2U4B1I6; -.
DR   GeneID; 101321605; -.
DR   OrthoDB; 4698638at2759; -.
DR   Proteomes; UP000245320; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd21985; HMG-box_PMS1; 1.
DR   CDD; cd03485; MutL_Trans_hPMS_1_like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT   DOMAIN          384..452
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        384..452
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          279..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          434..461
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        285..300
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   744 AA;  85073 MW;  D55A3AC9E25D84D4 CRC64;
     MDKEDVAIIW QKTRVSDHKM ALMSVLGTAV MGNMEPFQYH SEESQIYLSG FLPKHDADHS
     FTSLSTPERS FIFINSRPVH QKDILKLIRH YYNLKCLKES TRLYPIFFLK IDVPTADVDV
     NLTPDKSQVL LQNKESVLIA LENLMTTYYG SLTSTNSYES NKTDVSSDDM VVSKTTETDV
     LFTTMETSGN NYPNVDTSAI PFQNDVHNDK SGQNTNYCLN HHMHIGDHCD DHFNSENSSI
     DKNSGNTFQE IPMNNLSCED TQKEYSEVCF VGSVKQAQSE NGSKGHIDES GENEEEAVPE
     KSLEICVDDW SKGNVLKDSR GENIEPVKIL VPQESLACKV SNNNNNPSPE QKNLNESSYN
     KKSNVVDNKS GQLTAYDLIS NRVIKKPMSA SALFVQDHRA QFLTDNSKTS LEDATVQIEE
     LWKTLSEEEK LKYEEKATKD LERYNRQIKR AIEQESQVSL KDGKKRIKPT SAWNLAQKNK
     LKTSLSNQPK LDELFQSQIE KKTQNIKKVQ IPFSMENLKK NSDKHRKFDL EEKDESYLIH
     NLKFPDAWLI TSKTEIMLLN PYRVEEALLF KRLLENHKLP AEPLEKPIIL TESLFNGSHY
     LEILNKMTAD DQRYSGSTYL SDPRLTANGF KIKLIPGVSI AENYLEIEGM ANCLPFYGVM
     DLKEILNAIL NKNAKEVYEC RPRKVISYLE GEAVRLSRQL PMYLSKEDIQ DIICRMKQQF
     GNEIKGCVHG RPFFHHLTHL PEAT
//