ID A0A2U4B894_TURTR Unreviewed; 1294 AA.
AC A0A2U4B894;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Contactin-associated protein-like 2 isoform X2 {ECO:0000313|RefSeq:XP_019789445.1};
GN Name=CNTNAP2 {ECO:0000313|RefSeq:XP_019789445.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019789445.1};
RN [1] {ECO:0000313|RefSeq:XP_019789445.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019789445.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, paranodal septate junction
CC {ECO:0000256|ARBA:ARBA00004403}.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_019789445.1; XM_019933886.2.
DR GeneID; 101331395; -.
DR OrthoDB; 4255614at2759; -.
DR Proteomes; UP000245320; Chromosome 9.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033010; C:paranodal junction; IEA:UniProtKB-SubCell.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR15036:SF33; CONTACTIN-ASSOCIATED PROTEIN-LIKE 2; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1294
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015501462"
FT TRANSMEM 1225..1246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..144
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 150..331
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 336..515
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 517..554
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 553..605
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 762..926
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 927..965
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 987..1177
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 899..926
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1294 AA; 144076 MW; 4FF237793D4C970D CRC64;
MPVARGAGCG AALSFWLVGS ILCRAWTAPA TSRAGGWSPS DSDHYQWLQV DFGHRKQISA
IATQGRYSSS DWVTQYRMLY SDTGRNWKPY HQDGNIWAFP GNVNSDSVVR HDLQHPVIAR
YVRIVPLDWN GEGRIGLRIE VYGCSYWADV INFDGHVVLP YRFRNKKMKT LKDVIALKFK
TSESEGVILH GEGQQGDYIT LELKKAKLVF SLNLGSNQLG PIYGHTSVRT GSLLDDHHWH
SVVIERQGRS INLTLDRSTQ HFRTNGEFDY LDLDYEITFG GIPFSGKPSS SSRKNFKGCM
ENINYNGINI TDLARRKKLE PSNVGNLSFA CVEPYTVPVF FNATSYLEVP GRLHQDLFSV
SFQFRTWNPN GLLLFSHFAD NLGNVEIDLT DSKVSVHINI TQTKMSQIDI SSGSGLNDGQ
WHEVRFLAKE NFVILTIDGD EASAVRTNSP LQVKTGEKYF FGGYRNQMNN SSHSVLQPSF
QGCMQLIQVD DQLVNLYEVA QRRPGSFANV SIDMCAIIDR CVPNHCEHGG KCSQTWDSFI
CTCDETGYSG ATCHNSIYEP SCEAYKHLGQ TSNYYWIDPD GSGPLGPLKV YCNMTEDKVW
TIVSHDLQMQ TTVVGYNPEK YSVTQLIYSA SMDQISAITN SAEYCEQYIS YFCKMSRLLN
TPDGSPYTWW VGKANEKHYY WGGSGPGIQK CACGIERNCT DPKYYCNCDA DYKQWRKDAG
FLSYKDHLPV SQVVVGDTDR QGSEAKLSVG PLRCQGDRNY WNAASFPNPS SYLHFSTFQG
ETSADISFYF KTLIPRGVFL ENLGNTDFIK LELKSATEVS FSFDVGNGPV EIVVRSPSPL
NDDQWHRVTA ERNVKQASLQ VDRLPQQSRK APTEGHTRLE LYSQLFVGGA GGQQGFLGCI
RSLRMNGVTL DLEERAKVTS GFKSGCSGHC TSYGANCENG GKCIEKYHGY SCDCSNTAYD
GTFCNKDVGA FFEEGMWLRY NFQAPGSGAK ESGSRSENSL DPQNGAPDLA REEICFSFST
TKAPCILLYV SSFTTDFLAV LVKPTGSLQI RYSLGGTREP YNIDVDHRSM ANGQPHSVNV
TRHERTITLK LDHYPSVSYH LPSSSDTLFN SPKSLFLGKV IETGKIDQEI HKYNTPGFTG
CLSRVQFNQI APLKAALRQT NASARVHTQG ELVESNCGAS PLTLAPMSSA TDPWHLDHLD
SASADFPYNP GQGQAIRNGV NRNSAIIGGV IAVVIFTILC TLVFLIRYMF RHKGTYHTNE
AKGAESAESA DAAIMSNDPN FTETIDESKK EWLI
//
