ID A0A2U4B9V2_TURTR Unreviewed; 547 AA.
AC A0A2U4B9V2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Putative glycerol kinase 5 {ECO:0000256|ARBA:ARBA00013787};
DE EC=2.7.1.30 {ECO:0000256|ARBA:ARBA00012099};
DE AltName: Full=ATP:glycerol 3-phosphotransferase 5 {ECO:0000256|ARBA:ARBA00033026};
GN Name=GK5 {ECO:0000313|RefSeq:XP_019789854.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019789854.1};
RN [1] {ECO:0000313|RefSeq:XP_019789854.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019789854.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC EC=2.7.1.30; Evidence={ECO:0000256|ARBA:ARBA00001373};
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005190}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU003733}.
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DR RefSeq; XP_019789854.1; XM_019934295.2.
DR AlphaFoldDB; A0A2U4B9V2; -.
DR GeneID; 101325810; -.
DR InParanoid; A0A2U4B9V2; -.
DR OrthoDB; 2734344at2759; -.
DR UniPathway; UPA00618; UER00672.
DR Proteomes; UP000245320; Chromosome 4.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07793; FGGY_GK5_metazoa; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR037444; GK5_FGGY.
DR PANTHER; PTHR10196:SF68; GLYCEROL KINASE 5-RELATED; 1.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|RuleBase:RU003733, ECO:0000313|RefSeq:XP_019789854.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transferase {ECO:0000256|RuleBase:RU003733}.
FT DOMAIN 26..287
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 297..497
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61089 MW; 4DF307290DD4B3AC CRC64;
MPGPPTVAEQ TRPEQSAPDP RRAGFVLGLD VGSSVIRCHV YDRAARIRGS SAQKVKSLYP
QAGWVEIDPD ILWLQFVAVI KESVKAAGLE MNQIVGLGIS TQRATFITWD KKTGKHFHNF
ISWQDLRAIE LVKSWNSSLL MKLIHSSCRV LHFFTRSKRF LAASLFTFTT QHVSLRLAWI
LQNLAEVRKA IEEENCCFGT IDTWLLHKLT KGSEFATDFS NASTTGLFDP YEMCWSKLIT
SLLSIPLFLL PPVKDTSHNF GSVDEEIFGV PIPVVALVAD QQSAMFGECC FQTGDVKLTM
GTGTFLDINT GNNPQQSVGG FYPLIGWKIG QEVVCLAEGN AADTGTAIQW AQQLGFCCCC
LFVFVFADLF TDAAETEKMA RSLEDSEGVY FVPSFSGLQA PLNDPCACAS FMGLKSSTNK
YHLVRAILES IAFRNKQLYE VMQKEIHIPV RKIRADGGVC KNSFVMQMTS DLINETIDRP
VHVDMSCVGA ASLAGLAVGF WTDKEELKKL RQSEIVFKPQ KKWQEYEKNM GNWVKAVKRS
MNWYNKT
//
