ID A0A2U4BF53_TURTR Unreviewed; 830 AA.
AC A0A2U4BF53;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Semaphorin-4D isoform X2 {ECO:0000313|RefSeq:XP_019791845.2};
GN Name=SEMA4D {ECO:0000313|RefSeq:XP_019791845.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019791845.2};
RN [1] {ECO:0000313|RefSeq:XP_019791845.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019791845.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_019791845.2; XM_019936286.2.
DR AlphaFoldDB; A0A2U4BF53; -.
DR Proteomes; UP000245320; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProt.
DR CDD; cd05873; Ig_Sema4D_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF18; SEMAPHORIN-4D; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 703..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..467
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 521..603
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 623..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 92144 MW; C6858AE7B7FFAA39 CRC64;
MRMCAPVGGL LTALTVVFGT AVAFAPIPRI TWEHREVQLV QFHEPGIFNY SSLLLSEDKD
TLYVGAREAV FALNAHNISR KQHEAYWKVS EDKKAKCAEK GKSKQNLTSF KFLGKNEDGK
GRCPFDPAQS YTSVMVDGEL YSGTSYNFLG SEPIISRNSS HSPLRTEYAI PWLNEPSFVF
ADVIGESPEG GDDGDDKVYF FFTEVSVEYE FVFKLMIPRV ARVCKGDQGG LRTLQKKWTS
FLKARLICSR PDSNLVFNVL RDVFVLRSPS LKEPMFYGVF TPQLNNVGLS AVCAYNLSTA
EAVFSRGKYM QSATVEQSHT KWVRYNGAVP TPRPGACINR EARAANFSSS LNLPDKTLQF
VKDHPLMDDS VTPIDNRPRL IKSDVNYTQI VVDRTWALDG TVHDVMFVST DRGALHKAIS
LENNVHIIEE TQLFQDFEPV QTLLLSSKKG RRFVYAGSNS GVVQAPVAFC GKHGTCEDCV
LARDPYCAWS PAAAACIALY QTDGPSRGLI QEMSGDASAC PDKIKESYLQ HFFKHGGTAE
LKCSQKSNLA RVVWKFQNGV LKAESPKYSL VGRKNLLIFN LSEGDSGVYQ CLSEERVKNK
TVLQVVAKHV LEVKVVPRTP VASTSPVTRT EGSRITSKVS AGPTQGSFPQ TPALQVTTPS
SIALPSSPEG PTSMSCEPKI VINTVPQVHS EKTMYLKSSD NRLLMFLFLF FFVLFLCLFT
YNCYKGYLPG QCLKFRSAML LGKKQPTSDF LDCEQSVKET LVEQGSFSQQ NGGQPKPALD
TGYETEQDTM ASRLPTDRED SQKIDELPVR DRPFDVKCEL KFADSDADGD
//
