ID A0A2U4BG49_TURTR Unreviewed; 917 AA.
AC A0A2U4BG49;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Diacylglycerol kinase {ECO:0000256|RuleBase:RU361128};
DE Short=DAG kinase {ECO:0000256|RuleBase:RU361128};
DE EC=2.7.1.107 {ECO:0000256|RuleBase:RU361128};
GN Name=DGKH {ECO:0000313|RefSeq:XP_019792049.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019792049.2};
RN [1] {ECO:0000313|RefSeq:XP_019792049.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019792049.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-
CC octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00023371};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40328;
CC Evidence={ECO:0000256|ARBA:ARBA00023371};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-
CC phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608,
CC ChEBI:CHEBI:456216; EC=2.7.1.107;
CC Evidence={ECO:0000256|RuleBase:RU361128};
CC -!- PATHWAY: Lipid metabolism; glycerolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00005175}.
CC -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family.
CC {ECO:0000256|ARBA:ARBA00009280, ECO:0000256|RuleBase:RU361128}.
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DR RefSeq; XP_019792049.2; XM_019936490.2.
DR AlphaFoldDB; A0A2U4BG49; -.
DR UniPathway; UPA00230; -.
DR Proteomes; UP000245320; Chromosome 18.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004143; F:ATP-dependent diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR037607; DGK.
DR InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR11255; DIACYLGLYCEROL KINASE; 1.
DR PANTHER; PTHR11255:SF37; DIACYLGLYCEROL KINASE ETA; 1.
DR Pfam; PF00609; DAGK_acc; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00045; DAGKa; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361128};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU361128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361128};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361128}.
FT DOMAIN 83..218
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 336..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 917 AA; 101051 MW; 04957C7B71336D0A CRC64;
MWNISQGCIT GTPAPMPDPL SVTSAERVFL GSPPMACPAK VHTACKDLYH PICPLGQCRV
SVIPPIALNS TDSDGFCRAT FSFCVSPLLV FVNSKSGDNQ GVKFLRRFKQ LLNPAQVFDL
MNGGPHLGLR LFQKFDNFRI LVCGGDGSVG WVLSEIDKLN LNKQCQLGVL PLGTGNDLAR
VLGWGGSYDD DTQLPQILEK LERASTKMLD RWSIMTYELK LPAKASLLPE PPEASEEFYM
TIYEDSVAAH LTKILNSDEH AVVISSAKVL CETVKDFVAK VEKAHEKTLE RAVAADAVAN
KCSVLNEKLE QLLQALHTDS QASPVLPGIS PLIVEEDPVE SSSEESLCES KEQLLDDTTK
PSSQKTVKPR EIMLRANSLK KAVRQVIEEA GKVMDDQTVH SSEPVNQSFD YDSTETDESK
DESKEDDAKA SLTVKTAPRS PDGRASRSQT DSGSGPAVAA SKENLPVLNT RIICPGLRAG
LAASIAGSSI INKMLLANID PFGATPFIDP DPDSVDGYSE KCVMNNYFGI GLDAKISLEF
NNKREEHPEK CRSRTKNLMW YGVLGTRELL QRSYKNLEQR VQLECDGQYI PLPSLQGIAV
LNIPSYAGGT NFWGGTKEDD IFAAPSFDDK ILEVVAIFDS VQMAVSRVIK LQHHRIAQCR
TVKITIFGEE GVPVQVDGEA WVQPPGIIKI VHKNRAQMLT RDRAFESTLK SWEDKQKCDS
GKPVLRTHLY IQHAVDLATE EVSQMQLCSQ AAEELITRIC DAATIHCLLE QELAHAVNAC
SHALNKANPR FPESLTRDTA TEIAINVKAL YNETESLLVG RVPLQLESPH EERVSNALHS
VEVELQKLTE IPWLYYILHP NEDEEPPMDC TKRNSRSTVF RIVPKFKKEK VQKQKTSSQA
GPGDTESGSY EANSPGN
//
