ID A0A2U4BHC9_TURTR Unreviewed; 582 AA.
AC A0A2U4BHC9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Methyl-CpG-binding domain protein 1 isoform X27 {ECO:0000313|RefSeq:XP_019792617.1};
GN Name=MBD1 {ECO:0000313|RefSeq:XP_019792617.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019792617.1};
RN [1] {ECO:0000313|RefSeq:XP_019792617.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019792617.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_019792617.1; XM_019937058.1.
DR AlphaFoldDB; A0A2U4BHC9; -.
DR GeneID; 101339409; -.
DR OrthoDB; 5262043at2759; -.
DR Proteomes; UP000245320; Chromosome 13.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01396; MeCP2_MBD; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR002857; Znf_CXXC.
DR PANTHER; PTHR12396; METHYL-CPG BINDING PROTEIN, MBD; 1.
DR PANTHER; PTHR12396:SF59; METHYL-CPG-BINDING DOMAIN PROTEIN 1; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF02008; zf-CXXC; 2.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS51058; ZF_CXXC; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00509}.
FT DOMAIN 1..69
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 192..238
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT DOMAIN 306..354
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT REGION 80..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..283
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..534
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 64257 MW; 61B6E3590AA98654 CRC64;
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
LFDFKQGILC YPAPKAHSLA VPSRKRKKPS KPAKAQKRQV GPSKSEVRKE APRDETKADA
GTVPASLPAP GCCENCGISF SGDGTRRQRL KTLCKDCRAQ RIAFNREQRM FKLPHDVASG
LFCKCERRRC LRIVERSRGC GVCRGCQTRE DCGRCRVCLR PPRPGLRRQW RCVQRRCLRG
KHGRRRGGCD SKVAPRRRPP RTQPLPALPP SQPPESPELH PRALAPSPPA EFIYYCVDED
ELQPYTNRRQ NRKCGACAAC LRRMDCGHCD FCCDKPKFGG SNQKRQKCRW RQCLQFAMKR
LLPSVWAGSE DGAGPPAPYP RRKRPGSARR PRLGQTPKPP LATPMAQPDR AQTPVKQEAG
SGFVLPPPGT DLVFLREGAS SPVQVPGPAP ASTAALLQEA QCPGLSWVVA LPQVKQEKAD
AQEDWTPGTA ILTSPVLLPG CPSKAVDPGL PPVKQEPPDP EEDKEEENKD DPTADLAPEE
EAGGAGTPVI TEIFSLGGTR LRDTAVWLPR SKDLKKPGAR KQ
//
