ID A0A2U4BJX4_TURTR Unreviewed; 1190 AA.
AC A0A2U4BJX4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Nardilysin isoform X2 {ECO:0000313|RefSeq:XP_019793379.2};
GN Name=NRDC {ECO:0000313|RefSeq:XP_019793379.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019793379.2};
RN [1] {ECO:0000313|RefSeq:XP_019793379.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019793379.2};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR RefSeq; XP_019793379.2; XM_019937820.2.
DR AlphaFoldDB; A0A2U4BJX4; -.
DR Proteomes; UP000245320; Chromosome 1.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 5.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 286..414
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 440..625
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 631..912
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 917..1099
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 55..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..206
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 136174 MW; 512FDEED0BE70033 CRC64;
MLRRVTVAAV CATRRKLWCE AGRELAALWR IEARGRCEDS AATRPFPILT MPGRNKAKST
CSCPDRQPNG QDLGESGRVA RLGADESEEE GRRGPVSNVG DPEIVKSPSD PKQYRYIKLR
NGLQALLISD LSNVEGKMGD ATDDEEEEEE EEEEEEDDDD DDDDDEDSGA EIEDDEEGFD
DEDEFDDDDE HDDDDLDTED NELEELEERA EARKKTTEKQ QLQSLFLLLS KLTDRLWFKS
TYTKMSSTLL VETRKLYGVV GAESRSAPLQ HLAGWQEEEQ QGETDTVLSA AALCVGVGSF
ADPDDLPGLA HFLEHMVFMG SLKYPDENGF DAFLKKHGGS DNASTDCERT VFQFDVQRKY
FKEALDRWAQ FFIHPLMIRD AIDREVEAVD SEYQLARPSD ANRKEMLFGS LARPGHPMGK
FFWGNAETLK HEPKRNNIDT HARLREFWMH YYSAHYMTLV VQSKETLDTL EKWVTEIFSQ
IPNNGLPKPN FGHLTDPFDT PAFNKLYRVV PIRKIHALTI TWALPPQQQH YRVKPLHYIS
WLVGHEGKGS ILSYLRKKCW ALALFGGNGE TGFEQNSTYS VFSISITLTD EGYEHFYEVA
HTVFQYLKML QKLGPEKRIF EEIQKIEDNE FHYQEQTDPV EYVENMCENM QLYPLQDFLT
GDQLLFEYKP EVIAEALNQL VPQKANLVLL SGANEGKCDL KEKWFGTQYS MEDIENSWAE
LWESNFELNP DLHLPAENKY IATDFMLKAF DCPETEYPVK IVNTPQGCLW YKKDNKFKIP
KAYIRFHLIS PLIQKSAANV VLFDIFVNIL THNLAEPAYE ADVAQLEYKL VAGEHGLIIR
VKGFNHKLPL LFQLIIDYLA EFNSTPAVFT MITEQLKKTY FNILIKPETL AKDVRLLILE
YARWSMIDKY RALMDGLSLE SLLSFVRELK SQLFVEGLVQ GNVTSTESMD FLKYVVDKLN
FMPLEQEMPV QFQVVELPSG HHLCKVRALN KGDANSEVTV YYQSGARSLK EYTLMELLVM
HMEEPCFDFL RTKQTLGYHV YPTCRNTSGI LGFSVTVGTQ ATKYNSEVVD KKIEEFLSSF
EEKIENLTED AFNTQIEALK SFSKSDLVNW FKAHRGPGSK MLSVHVVGFG KYEPEEDGTP
SGEDSNSSCE VMQLTYLPTS PLLADCTIPV IDIRAFTSRL NLLPYHKIVK
//