ID A0A2U4BMV0_TURTR Unreviewed; 2593 AA.
AC A0A2U4BMV0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=ATP-binding cassette sub-family A member 12 isoform X1 {ECO:0000313|RefSeq:XP_019794532.2};
GN Name=ABCA12 {ECO:0000313|RefSeq:XP_019794532.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019794532.2};
RN [1] {ECO:0000313|RefSeq:XP_019794532.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019794532.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_019794532.2; XM_019938973.2.
DR STRING; 9739.ENSTTRP00000004018; -.
DR InParanoid; A0A2U4BMV0; -.
DR OrthoDB; 6951at2759; -.
DR Proteomes; UP000245320; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF29; GLUCOSYLCERAMIDE TRANSPORTER ABCA12; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840,
KW ECO:0000313|RefSeq:XP_019794532.2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1064..1082
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1108..1130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1142..1165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1171..1193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1247..1268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1746..1767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1987..2009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2021..2037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2069..2087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2099..2123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2186..2207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1346..1577
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 2254..2489
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 2593 AA; 293146 MW; 4210AB41836EDF26 CRC64;
MASPSHQLHV LVWKNWLGVK RQPLWTLVLI LWPVTIFLIL AITRTKFPPK PKATCYLAPR
NLPSTGFFPL LQTLLCDTDS KCKDTPYGPQ DLLRRQGIDD AQFKDSEILR KSPNLEKDSN
LSLQSTEVPE KRHASLATVF PSPRSDLESD GTYTFNGSQV LAWILSLEKQ NSTSEDIRRE
LCESYPRYTA DYAFSWTTLG KNVFNIFCLS NMTLLESSLR ELTNQFSQLS RDPNNQKTVF
QEMVKVLSFF SQVQEQTALW QLLSSFPNVF RNDTTLSNLF DVLRSANSVL LAVQRVYPRV
TTNEGFRALH KSVKHLLYTL DSPSQGGSDN TTHVWSEEDG QSLSPSSLAA QLLILENFED
ALLNISVDSP YIPYLACVRN VTDNLARGSK ENLRLLHSTI RFQKSFLQNG SYEDYFPPVP
EVLKSKLSQL GNLTKLLCEP ETFSSLEKMC QLSSMDFGNL CEESAFHVQL LKAAEFSTEI
ATSLLYHDNI LSEKLRDLLS GDPSKINLDM DRFLEEALQM NYLENITRLM PKIQAMLHVN
NSADTLEKPG QLIEMFKNVE ELKEELRRTT GMSNRSIDNL LAIPTPDNRA EIISSVFWWH
SCDVNVTSPK LEDAMKEFCN IPLPERSRLS YLIGLTLLHY LDIYNFTYKV FFPRENQKPV
EKMIELFIRL KEILNQMASV TRPLLDKMRS LKQMHLSRSF PLTQAMYRNN RLNTPQGSFS
TISQALCSQG ITTEYLVAML PSSQRQGGNH TKDFLTYKLS KEQIAAKYGI PLHATPFCFS
LYKDIINMPA GPVIWAFLKP MLLGRILYAP YTPITKAIME KSNVTLRQLA ELKEKSQEWV
DKSPFFMNSF HLLNQTIPIL QNTLRNPFVQ VFVKFSVGLD AVELLKQMDE LDILRLKLEN
GIDLIDHLTT LSSLTVNISS CILYDRIQAA ESIDEMEGEA KRLHKSNELF GSVIFKLPSD
SSQHRRYDSE NVSLPPVVKY TIRMSLKTSQ TTRSIRTKIW APGPHNSPSN NQIYGRAFIY
LQDSIERAVV ELQTGRNSQE IAVQVQAIPY PCYMKDNFLT SVSYSLPIVL MVAWVIFIAA
FVKKLVYEKD LRLHEYMKMM GVNSCSHFFA WIIESVAFLL VTIIILIIIL KFGNILPKTN
GFILFLYFSD YSFSVLAMSY LISVFFNNTN IAALIGSLIY IIAFFPFIVL VTIENELSCI
IKVFMSLLSP TAFSYASQYI ARYEEQGIGL QWENMYSSPV QDDTTSFGWL CCLILADSFI
YFLIAWYVRN VFPGTYGMAA PWYFPFLPSY WKERLGCAEV KHEKSNGLIF TNIMMQNTIP
SASKTSPEYV FPSNTESEPK DLTVGVALHG VTKNYGSKIA VANLSLNFYE GHITSLLGPN
GAGKTTTISL LTGLFEASAG TILVYGKDIK TDLHTVRKNL GVCMQHDVLF SYLTTKEHLL
LYGSIKAPHW TKKQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV
ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL EEGGLRCCGS
PFYLKEAFGD GYHLTLTKKK SPNVNASAVC DTTAVTAVIQ SHLPEAYLKE DIGGELVYVL
PPFSTNVSGA YLSLLRTLDN GLSDLNIGCY GISDTTMEEV FLNLTKGSQK NNDMSFEHLT
QKKIGNSSTS VISTHDDLSV SSSNFTDRDD KILTRGERLD GFGLLLKKVM AILIQRFHHT
RRNWKGFIAQ VILPIIFVTT AMGFGTLRSS SDSYPEIQIS PSLYGTSEQT TFYANSHPST
KELVSAMWSF PGIDNMCLNI SDPRCLEKDS LGKWNSSEDP ITNFGVCSCS ENIQECPKFN
YSPPHRRTYS SHLIYNLTDH HLENYLISTA NKFMQKRYGG WSFGLPLTKD LRFDITAVPA
NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR VNMSKDDAAR HGIILYSHPY PGVQDQEQAT
MSSLIDILVA LSILLGYSVT TASFVTYVVR EHQNKAKQLQ HISGIGVICY WVTNFIYDMA
FYLVPVAFSV GVIAIFKLPA FYSENNLSAV SLLLLLFGYA SFSWMYLLAG LFHETGVAFI
TYVCINLFLG INSIVSLSVV YFLSKEKPND TTLELISETL KRIFLIFPQF CFGYGLIELS
QQQSVLDFLK AYGVEYPSET FEMDKLGAMF VALVCQGTVF FFLRLLINEW LINKLRRFFK
KFRSPPVIET IVEDEDVWTE RFRVENGANE CDLVQLHHLT KTYHLIHKKI IAVNNISVGI
PAGECFGLLG VNGAGKTTIF KMLTGDIIPT GGNILIRNKI GSLAHADSDS SLIGYCPQED
ALDDLVTVEE HLYFYARIHG IPEKDIKEAV HKLLRRLYLE PYKDKTTSMC SYGTKRKLST
ALALIGKPSI LLLDEPSSGM DPKSKRHLWK IISEEVQNKC AVILTSHSME ECEALCTRLA
IMVNGRFQCI GSLQHIKSRF GRGFTVKVHV KNVKVSMEPL TRFMQLHFPK TYLKDQHLSM
LEYHVPVTAG GVANIFDLLE TNKTALNITN FLVSQTTLEE VFINFAKDQK CYETADTSSQ
VSTVSTDSQD DQL
//
