ID A0A2U4BQY7_TURTR Unreviewed; 1153 AA.
AC A0A2U4BQY7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=PDZ domain-containing protein 8 isoform X1 {ECO:0000313|RefSeq:XP_019795625.1};
GN Name=PDZD8 {ECO:0000313|RefSeq:XP_019795625.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019795625.1};
RN [1] {ECO:0000313|RefSeq:XP_019795625.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019795625.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019795625.1; XM_019940066.2.
DR AlphaFoldDB; A0A2U4BQY7; -.
DR GeneID; 101333044; -.
DR InParanoid; A0A2U4BQY7; -.
DR OrthoDB; 3681901at2759; -.
DR Proteomes; UP000245320; Chromosome 16.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:InterPro.
DR GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:InterPro.
DR CDD; cd20825; C1_PDZD8; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd21674; SMP_PDZD8; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039275; PDZD8.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR031468; SMP_LBD.
DR PANTHER; PTHR21519; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21519:SF1; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51847; SMP; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transport {ECO:0000256|ARBA:ARBA00023055};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 89..292
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 365..448
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 839..890
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 65..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1032..1059
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 73..87
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..599
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1153 AA; 128526 MW; F15E9C38E3DE89B9 CRC64;
MGLLLMILAS AVLGSLLTLL TQFLLLYRKQ PEPPPDEAAR AADGFRYIKP VPDLALREYL
YGGGGAEEPS GGPPEGGPTP APETPAPPTR ETCYFLNATI LFLFRELRDT ALARRWVTKK
IKVEFEELLQ TKTAGRLLEG LSLRDVFLGE AVPFIKTIRL LRPVVPSATG EPDVPEGEAL
PATSPEELAF EAEVEYSGGF HLAIDVDLVF GKSAYLFVKL SRVVGRLRFV LTRVPFTHWF
FSFVEDPLID FEVRSQFEGR PMPQLTSIIV NQLKKVIKRK HTLPSYKIRF KPFFPFQTLQ
GFEEDDEEHI HIQQWALTEG RLKVTLLECS RLLIFGSYDR EANIHCTLEL SSGLWEEKQR
SSIKTVELIK GNLQSVGLTL RLVQSTDGYA GHVIIETVAP NSPAAIADLQ RGDRLIAIGG
VKITSTLQVL KLIKQAGDRV LVYYERPVGQ SNQGAVLQDN FGQLEDNFLI GPCQPNYEEE
TSGLAVDAEN RDLDSEFEDL ASDVRAQTEV KDEAQSLSHS PKRTPTTLSV KPLGTISPVL
NRKLVVGSYP PPPKLPSKEE NKPLALKSSE ITEPAQVSKP TQGSTFKPPV PPRPQVKVPL
PSADAPNQAE PDILVEKPEK VLPPPAADKP AEKQAKNLDH VEEAATAKQF PAKQEVAKDL
TSESSCTPKD SSDDHQTWES SEILYRNKLG KWTRTRASCL FDIEACHRYL NIALWCRDPF
KLGGLICLGH VSLKLEEVAL GCLATSNMEY LSKFRLEAPS PKAMVTRTAL RNLSMQKGFN
DKFCFGDITV HFKYLKEGEP DHHVVTNLEK EKELHLVEEV SALPKEEHFV GQMGLTENKH
SFQDTQFQNP TWCDYCKKKV WTKAASQCMF CAYVCHKKCQ EKCLAETPLC GATDQRIDRA
LKNLRLEGQE ALLGLPPRVD AEAGKSVNRM TGLTRHIINT SSRLLNLRQV SKTRLSEPGT
DLVEPSPKHT PNTSDNEGSD TEICGPNSPS KQGNNTGIKL VRKEGGLDDS VFIAVKEIGR
DLYRGLPTEE RIQKLEFMLD KLQNEIDQEL EHNNSLVREE KETTDTRKKS LLSAALAKSG
ERLQALTLLM IHYRAGIEDI ESLESLSLDQ HSKKISKYTD DTEEDLDSEI TQLIDSQPFS
SISDDLFGPS ESV
//
