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Database: UniProt
Entry: A0A2U4BUN5_TURTR
LinkDB: A0A2U4BUN5_TURTR
Original site: A0A2U4BUN5_TURTR 
ID   A0A2U4BUN5_TURTR        Unreviewed;       680 AA.
AC   A0A2U4BUN5;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 2.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Dynein axonemal assembly factor 1 {ECO:0000256|ARBA:ARBA00024429, ECO:0000256|RuleBase:RU364076};
GN   Name=DNAAF1 {ECO:0000313|RefSeq:XP_019796910.2};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019796910.2};
RN   [1] {ECO:0000313|RefSeq:XP_019796910.2}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019796910.2};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Cilium-specific protein required for the stability of the
CC       ciliary architecture. Plays a role in cytoplasmic preassembly of dynein
CC       arms. Involved in regulation of microtubule-based cilia and actin-based
CC       brush border microvilli. {ECO:0000256|RuleBase:RU364076}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU364076}.
CC   -!- SIMILARITY: Belongs to the DNAAF1 family.
CC       {ECO:0000256|ARBA:ARBA00006453, ECO:0000256|RuleBase:RU364076}.
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DR   RefSeq; XP_019796910.2; XM_019941351.2.
DR   AlphaFoldDB; A0A2U4BUN5; -.
DR   STRING; 9739.ENSTTRP00000001939; -.
DR   InParanoid; A0A2U4BUN5; -.
DR   OrthoDB; 129594at2759; -.
DR   Proteomes; UP000245320; Chromosome 19.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0060271; P:cilium assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR45973:SF19; DYNEIN AXONEMAL ASSEMBLY FACTOR 1; 1.
DR   PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR   Pfam; PF14580; LRR_9; 1.
DR   SMART; SM00365; LRR_SD22; 3.
DR   SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|RuleBase:RU364076};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU364076};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Leucine-rich repeat {ECO:0000256|RuleBase:RU364076};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Repeat {ECO:0000256|RuleBase:RU364076}.
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          318..345
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        54..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        567..587
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  75345 MW;  1F98177F31B78ACC CRC64;
     MNRDASEPVA DGGAEQDCAR EPGLEPAVEE SAGDHGNAGQ GGRKEEINDP KETCVGPSDT
     SYLSEQKHSG DSWSEGHLAQ QRDDKEDRGP RMTKNFLRKL CKQHKLYITP ALNDALYLHY
     KGFDRIENLE EYTGLRCLWL ECNGIQKIEN LEAQTELRCL FLQVNLLHKI ENLEPLQKLD
     ALNISNNYIK TIENLSCLPV LNTLQMAHNH LETVEDVQHL KECLKLCVLD LSHNQLSDPE
     ILSILESMPN LRVLNLMGNP VIRNIPNYRR TLTVRLKHLT YLDDRPVFPK DRACAEAWAQ
     GGYKAEQEER QQWESRERKK ITDSIEALAA IKRQAEERKQ QKASQEQGCS QLTVDFCSGE
     MLAPDSARDL GATVEGEEAP EKDRERWQKT ELFVKESFEA KDELFPEKSE ESSLPEELPV
     DADGEPGAAL PAKAPPPSPG AAWEESAPQT VATESASGTE LCGAEDLEAI RLETKEKLFI
     DDLPDLEDVD AGGSPGDQHK KMCFPKITAI SSLGDDSDPE LDYTSLPVLE NASTDPLSSI
     FAVSKDTSRK AETETPFTGI FKAAAERDLA THSRDTKAPR PLIQELDDDE PSGQPPWPPA
     CKREAAPAPC SEDRHGDLLL ASPPGTVTQL SRLQGPKASQ GEMDCGPPKP RAGGHLGLCP
     RNPVFSERVT HDLSRDHGDR
//
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