ID A0A2U4BVF7_TURTR Unreviewed; 301 AA.
AC A0A2U4BVF7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 6 {ECO:0000256|ARBA:ARBA00015761};
DE AltName: Full=Apo-1 antigen {ECO:0000256|ARBA:ARBA00032338};
DE AltName: Full=Apoptosis-mediating surface antigen FAS {ECO:0000256|ARBA:ARBA00032502};
DE AltName: Full=FASLG receptor {ECO:0000256|ARBA:ARBA00030181};
GN Name=FAS {ECO:0000313|RefSeq:XP_019797124.1,
GN ECO:0000313|RefSeq:XP_019797193.1, ECO:0000313|RefSeq:XP_033697549.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019797193.1};
RN [1] {ECO:0000313|RefSeq:XP_019797124.1, ECO:0000313|RefSeq:XP_019797193.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019797124.1,
RC ECO:0000313|RefSeq:XP_019797193.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane raft {ECO:0000256|ARBA:ARBA00004285}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_019797124.1; XM_019941565.2.
DR RefSeq; XP_019797193.1; XM_019941634.2.
DR RefSeq; XP_033697549.1; XM_033841658.1.
DR GeneID; 101321590; -.
DR OrthoDB; 24515at2759; -.
DR Proteomes; UP000245320; Chromosome 16.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08316; Death_FAS_TNFRSF6; 1.
DR CDD; cd10579; TNFRSF6; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR008063; Fas_rcpt.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR033998; TNFRSF6_death.
DR InterPro; IPR033999; TNFRSF6_N.
DR PANTHER; PTHR46874; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR PANTHER; PTHR46874:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01680; TNFACTORR6.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Receptor {ECO:0000313|RefSeq:XP_019797124.1,
KW ECO:0000313|RefSeq:XP_019797193.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 144..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 50..93
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 50..93
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 94..131
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 94..131
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 212..280
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 301 AA; 34631 MW; 947FDA3628781DDC CRC64;
MLKLSKNITK RESCGEGLYR EHEFCCQPCP PGKRKSDDCK IDGGEPECVL CAEGVEYTDK
NHHSFNCRRC RVCDGEHGLE VEKNCTRTQN TKCRCKPNFF CNVSLCEHCN PCTTCEHGII
EKCTPTSNTK CREVFQFTGS RSNLLNLLLL LILIPIPAVI YWEVKRRRRN RKNGHQKSMA
SNTEMMPLNF TDIDLGKHII SIAEQMKITE VKEFVRKNGM EETKIDEIKH DNPQDTAEQK
VQLLRNWYQS HGKKDAYCTL IKSLRKAKLH ALAEKIQDIV QKDITSEHEN ADLQNENESL
A
//
