ID   A0A2U4C012_TURTR        Unreviewed;      1097 AA.
AC   A0A2U4C012;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Structural maintenance of chromosomes protein 6 isoform X1 {ECO:0000313|RefSeq:XP_019798805.1};
GN   Name=SMC6 {ECO:0000313|RefSeq:XP_019798805.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019798805.1};
RN   [1] {ECO:0000313|RefSeq:XP_019798805.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019798805.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC       {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the SMC family. SMC6 subfamily.
CC       {ECO:0000256|ARBA:ARBA00006793}.
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DR   RefSeq; XP_019798805.1; XM_019943246.2.
DR   AlphaFoldDB; A0A2U4C012; -.
DR   STRING; 9739.ENSTTRP00000015079; -.
DR   GeneID; 101320197; -.
DR   InParanoid; A0A2U4C012; -.
DR   OrthoDB; 78166at2759; -.
DR   Proteomes; UP000245320; Chromosome 14.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   PANTHER; PTHR19306; STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6; 1.
DR   PANTHER; PTHR19306:SF6; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6; 1.
DR   Pfam; PF13476; AAA_23; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT   DOMAIN          56..263
FT                   /note="Rad50/SbcC-type AAA"
FT                   /evidence="ECO:0000259|Pfam:PF13476"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1078..1097
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          236..263
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          289..344
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          377..457
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          667..799
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1097 AA;  127223 MW;  3A2915E599C0C0E4 CRC64;
     MAKRKEGNFF SPGNAKRPRQ EELDDFDKDG DEDQCTVSFT NGTSALTAAE VGIIESIQLR
     NFMCHSMLGP FKFGSNVNFV VGNNGSGKSA VLTALIVGLG GKAVATNRGS SLKGFVKDGQ
     NSADISITLR NRGDDAYRAN VYGHSIIVQQ HISMDGSRSY KLKSETGALV STRKEELIGI
     LDHFNIQVDN PVSVLTQEMS KQFLQSKNEG DKYKFFMKAT QLEQMKEDYS YIMETKERTK
     EQINQGEERL TELKRQCLEK EERFQSIAGL STMKTNLEYL KHEMAWAVVN EIEKQLNAIR
     DNIKIGEDRA ARLERKTEEQ QVRLNEAEKK YKDIQDKLEK ISQETNARAP ECMALKADLT
     SKKRAYNEAE VLYNHSLNEY RALKKDDEQL CKRIEELRKS ADQSLEPERL ERQKKISSLK
     ERVKVLQDQE SSVNQEIEQF QQAVEKDKEE HTRIKREELD VKNTLNYNQR QLKELKDSKT
     DRLKRFGPHV PALLEAIDDA YRRRHFTRKP VGPLGACIHL RDTELALAIE SCLKGLLQAY
     CCDNHADERV LQALMERFYS PGTSRPQIIV SEFQNKVYDV RHRAAYHPEF PTVLTALEID
     NAVVTNSLID MRSIETVLLI KNNSVARAVM QSQKPPKNCR EAFTADGDQV FAGRYYSSEY
     TRPKFLSRDV DSEISDLENE VENKKAQISN LQQHLSALEK DIKHNEELLR RCQLHYKELK
     MKIRRSTSEI RELENIEEHQ SVDIATLEDE AQENKIKMKM VEKNMEQQKE NMEHFKSLKI
     EAENKYDAIK QKINQLSELA DPLKDELNLA DSEVDNQKRG KRHYEDKQKE HLDTLNKKKR
     ELDMKEKELE EKMSQARQIC PERIEVKKSA SILDKEINRL RQKIQAEHAS HGDREEIMRQ
     YQEARETYLD LDNKVRTLKR FIKLLEEIMT NRYKTYQQFR RCLTLRCKLY FDNLLSQRAY
     CGKMNFDHKN ETLTISVQPG EGNKAAFNDM RALSGGERSF STVCFILSLW SIAESPFRCL
     DEFDVYMDMV NRRIAMDMIL KMADSQRFRQ FILLTPQSMS SLPPSKLIRI LRMSDPERGQ
     TTLPFRPVSQ GEEEDRG
//