ID A0A2U4C050_TURTR Unreviewed; 1298 AA.
AC A0A2U4C050;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 1 isoform X11 {ECO:0000313|RefSeq:XP_019798799.2};
GN Name=LTBP1 {ECO:0000313|RefSeq:XP_019798799.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019798799.2};
RN [1] {ECO:0000313|RefSeq:XP_019798799.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019798799.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_019798799.2; XM_019943240.2.
DR Proteomes; UP000245320; Chromosome 14.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 11.
DR Gene3D; 2.10.25.10; Laminin; 16.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 12.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 15.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1298
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030058325"
FT DOMAIN 73..105
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 231..276
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 300..337
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 351..397
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 536..577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 659..699
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 700..740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 741..781
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 782..822
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 823..864
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 924..978
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1101..1154
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1239..1283
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 426..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 77..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 95..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1298 AA; 142301 MW; 019E80EADB4E7021 CRC64;
MDTKLMCLLF FFSLPPLLVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK GNTTTLISEN
GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT GKLCQIPVHG AGVPKLYQHS
QQSGKALGTH VVHSTHTLPL TMTSQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRVDGP
TGQKVKEAQP GQSQVSYQGL PVQKTQTVHS SYSHQQVIPH VYPVAAKTQL GRCFQETVGS
QCGKALPGLS KQEDCCGTVG TSWGFHKCQK CPKKPSYHGY NQMMECLQGY KRVNNTFCQD
INECQLQGVC PNGECLNTMG SYRCTCKIGF GPDPTFSSCV PDTPVISEEK GPCYRLVSSG
RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAKEE PVEALTFSRE QGPGAAEPEV
ATVPPEKEIP SLDQEKTKLE PSQPQLSPGI STIHLHPQFP VVIEKTSPPV PVEVAPEAST
SSASQVIAPT QVTEINECTV NPDICGAGHC INLPVRYTCI CYDGYKFSEQ QRKCVDIDEC
AQAQHLCSQG RCENTEGSFL CICPAGFMAS EEGTNCIDVD ECLRPDVCGE GHCVNTVGAF
RCEYCDSGYR MTPGGHCEDV DECLTPSTCP DEQCVNSPGS YQCVPCTEGF RGWNGQCLDV
DECLEPDICT NGTCSNLEGS YMCSCHKGYT PTPDHKHCKD VDECQQGNLC INGQCKNTEG
SFRCTCGQGY QLSATKDQCE DIDECQHRHL CSNGQCRNTE GSFRCVCDQG YRASALGDHC
EDINECLEDN SVCQGGDCIN TEGSYDCTCP DGFQLNDNKG CQDINECEQP GLCGPHGECL
NTDGSFHCVC EQGFSISADG HTCEDVNECE LLSGVCGEAF CENVEGSFLC VCVDENQEYS
PMTGQCRSRA SADLEVDQPK EEKKECYYNL NDASLCDNVL APNVTKQECC CTSGAGWGDN
CEIFPCPVLG TAEFTEMCPR GKGFVPTGES SYDVDGENYK DADECLLFGQ EICKNGFCLN
TQPGYECYCK QGTYYDPIKL QCFDIDECQD PNSCIDGQCV NTEGSYNCFC THPMVLDASE
KRCIRPTESH EQIEETDVYQ DLCWEHLSDE YVCSRPLVGK QTTYTECCCL YGEAWGMQCA
LCPMKDSDDY AQLCNIPVTG RRQPYGQDAL VDFSEQYAPE ADPYFIQDRF LNSFEELQAE
ECGILNGCEN GRCVRVQEGY TCDCFDGYHL DMAKMTCVDV NECDELNNRM SLCKNAKCIN
TEGSYKCVCL PGFVPSDKPN YCTPLNTALN LEKDSDLE
//
