ID A0A2U4C347_TURTR Unreviewed; 1937 AA.
AC A0A2U4C347;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Myosin-8 {ECO:0000313|RefSeq:XP_019799811.2};
GN Name=MYH8 {ECO:0000313|RefSeq:XP_019799811.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019799811.2};
RN [1] {ECO:0000313|RefSeq:XP_019799811.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019799811.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_019799811.2; XM_019944252.2.
DR STRING; 9739.ENSTTRP00000007970; -.
DR InParanoid; A0A2U4C347; -.
DR OrthoDB; 2877572at2759; -.
DR Proteomes; UP000245320; Chromosome 20.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF35; MYOSIN-8; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 35..84
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 88..781
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 658..680
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1126..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1126..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 181..188
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1937 AA; 222705 MW; 4A3AEF674CA7E291 CRC64;
MSASLDAEMA VFGEAAPYLR KSEKERIEAQ NKPFDAKSSV FAVEPKESYV KSIIQSKEGG
KVTVKTECGA TLTVREDQVF PMNPPKFDKI EDMVMMTHLH EPAVLYNLKE RYAAWMIYTY
SGLFCVTINP YKWLPVYNPE VVAAYRGKKR QEAPPHIFSI SDNAFQFMLT DRENQSILIT
GESGAGKTVN TKRVIQYFAT IAVTGEKKKD ETGKMQGTLE DQIISANPLL EAFGNAKTVR
NDNSSRFGKF IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QITSNKKPDL
IDMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDRAID ILGFTPEEKV SIYKLTGAVM
HYGNMKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK ALCYPRVKVG NEYVTKGQTV
QQVYNAVGAL AKAVYEKMFL WMVTRINQQL DTKQPRQYFI GVLDIAGFEI FDYNSLEQLC
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WEFIDFGMDL AACIELIEKP LGIFSILEEE
CMFPKATDTS FKNKLYDQHL GKSANFQKPK VVKGRAEAHF SLIHYAGTVD YNIAGWLDKN
KDPLNDTVVG LYQKSAMKTL ASLFSTYASA EADSGAKKGA KKKGSSFQTV SALFRENLSK
LMTNLRSTHP HFVRCIIPNE TKTPGAMDHE LVLHQLRCNG VLEGIRICRK GFPSRILYGD
FKQRYKVLNA SAIPDGQFID SKKASEKLLA SIDIDHTQYK FGHTKVFFKA GLLGLLEEMR
DEKLAQIITR TQAICRGFLM RAEYQKMLQR REALFCIQYN VRAFMNVKHW PWMKLFFKIK
PLLKSAETEK EMTTMKEEFQ KTKDELAKSE AKRKELEEKM VTLLKEKNEL QLQVQSEADA
LADAEERCEQ LIKNKIQLEA KIKEVTERAE DEEEINSELT AKKRKLEDEC SELKKDIDDL
ELTLAKVEKE KHATENKVKN LTEEMAGLDE VIGKLTKEKK ALQEAHQQTL DDLQAEEDKV
NTLNKAKAKL EQQVDDLEGS LEQEKKLRMD LERAKRKLEG DLKLAQESIV DIENDKQQLD
EKFKKKEFEI SNLLSKIEDE QAVEIQLQKK IKELQARIEE LEEEIEAERA SRAKAEKQRS
DLSRELEEIS ERLEEAGGAT SAQIEMNKKR EAEFQKMRRD LEEATLQHEA TAATLRKKHA
DSVAELGEQI DNLQRVKQKL EKEKSELKME IDDLSSNAET ISKAKGNLEK MCRALEDQVS
ELKTKEEEQQ RLLSDLTAQR ARLQTEAGEY SRQLDEKDAL VSQLSRTKQA STQQIEELKC
QLEEETKAKS ALAHALQSSR HDCDLLREQY EEEQEAKAEM QRALSKANSE VAQWRTKYET
DAIQRTEELE EAKKKLAQRL QEAEEHVEAV NAKCASLEKT KQRLQNEVED LMLDMGRSNA
ACAALDKKQR NFDKVLSEWK QKYEETQAEL EGSQKESRSL STELFKVKNA YEESLEHLEM
LKRENKNLQQ EISDLTEQIA EGGKQIHELE KIKKQVEQEK CEIQAALEEA EASLEHEEGK
ILRIQLELNQ VKSEVDKKIA EKDEEIDQLK RNHIRVVETM QSTLDAEIRS RNDALRVKKK
MEGDLNEMEI QLNHANRLAA ESLRNYRNTQ GILKDTQLHL DDALRGQEDL KEQLAIVERR
ANLLQAEIEE LRATLEQTER SRKTAEQELL DASERVQLLH TQNTSLINTK KKLENDVSQL
QSEVEEVIQE SRNAEEKAKK AITDAAMMAE ELKKEQDTSA HLERMKKNLE QTVKDLQHRL
DEAEQLALKG GKKQIQKLEA RVRELEGEVE SEQKRNAEAV KGLRKHERRV KELTYQTEED
RKNVLRLQDL VDKLQAKVKS YKRQAEEAEE QSNANLAKFR KLQHELEEAE ERADIAESQV
NKLRVKSREV HTKVSPE
//
