ID   A0A2U4C5L8_TURTR        Unreviewed;      1372 AA.
AC   A0A2U4C5L8;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 2.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=F-actin-uncapping protein LRRC16A isoform X4 {ECO:0000313|RefSeq:XP_019800666.2};
GN   Name=CARMIL1 {ECO:0000313|RefSeq:XP_019800666.2};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019800666.2};
RN   [1] {ECO:0000313|RefSeq:XP_019800666.2}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019800666.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CARMIL family.
CC       {ECO:0000256|ARBA:ARBA00007298}.
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DR   RefSeq; XP_019800666.2; XM_019945107.2.
DR   STRING; 9739.ENSTTRP00000012937; -.
DR   Proteomes; UP000245320; Chromosome 10.
DR   Gene3D; 6.10.140.1850; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR031943; CARMIL_C.
DR   InterPro; IPR041245; CARMIL_PH.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR24112:SF39; F-ACTIN-UNCAPPING PROTEIN LRRC16A; 1.
DR   PANTHER; PTHR24112; LEUCINE-RICH REPEAT, ISOFORM F-RELATED; 1.
DR   Pfam; PF17888; Carm_PH; 1.
DR   Pfam; PF16000; CARMIL_C; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   SMART; SM00368; LRR_RI; 5.
DR   SUPFAM; SSF52047; RNI-like; 2.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT   DOMAIN          26..119
FT                   /note="CARMIL pleckstrin homology"
FT                   /evidence="ECO:0000259|Pfam:PF17888"
FT   DOMAIN          786..1079
FT                   /note="CARMIL C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16000"
FT   REGION          954..976
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          989..1008
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1036..1158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1189..1372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1036..1069
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1102..1151
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1189..1204
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1241..1272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1312..1359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1372 AA;  151635 MW;  7DA24EB45F500376 CRC64;
     MTEESSEVPR ELIESIKDVI GRKIKIALKK KVKLEVKGDK VENKVLVLTS CRAFLVTARI
     PTKLEVTFSY LEIHGVLCSK PTQMVVETEK CSISLKMASP EDVSEVLAHI GTSLRKIFPG
     FSPLRIMKKV CMEPSERLAS LQALWDSQTV AEQGPCGGFS QMYACVCDWL GFSYREEVQW
     DVDTIYLTQD TRELNLQDFS HLDHRDLIPI IAALEYNQWF TKLSSKDLKL STDVCEQILR
     VVSRSNRLEE LVLENAGLRT DFAQKLASAL AHNPNSGLHT INLAGNPLED RGVSSLSIQF
     AKLPKGLKHL NLSKTSLSPK GVNSLSQSLS ANLLTATTLN HLDLSGNILR GDDLSSMYSF
     LAQPNAIAHL DLSNTECSLD MVCGALLRGC LQYLAVLNLS RTVFSHRKGK EAPPSFKQFF
     SSSLALMQIN LSGTKLSPEP LKALLLGLAC NHNLKRVSLD LSNCELRSGG AQVLEGCIAE
     IHNITSLDIS DNGLESDLST LIVWLSKNRS IQHLALGKNF NNMKSKNLTP VLDNLVQMIQ
     DEESPLQSLS LADSKLKNEV TIIINALGSN TSLTTVDISG NGMGDMGAKM LAKALQINTK
     LRTVIWDKNN ITAQGFQDIA VAMEKNYTLR FMPIPMYDAS QALKTNPEKT EEALQKIENY
     LLRNHETRKY LQEQAYRLQQ GIVTSTTQQM IDRICVKVQD HLNSLRNCGG DAVQEDLKSA
     ERLMRDAKNS KTLLPNLYHA GGASWAGASG LLSSPIQETL ESMAGEVTRV VDEQLKALLE
     SMVDAAENLC PNVMKKAHIR QDLIHASTEK ISIPRAFVKN VLLEQSGIDI LNKISEVKLT
     VASFLSDRIV DEILDALSHC HHKLADHFSR RGKALPQQDS LEIELPEEKP VKRSIVMVEE
     LTEIERLEDL DTCMMTPKSK RKTIHSRMLR PVSRAFEMEF DLDKALEEVP IHVEDPPFPS
     IRQEKQSSGF ISDLPSEEGK KLEHFTKLRP KRAKKQQSTH AAGCATSLVS QDGEQNGLMG
     RVDEGVDEFF TKKVTKMDSK RGSARGSESH ELSEGGDEKK KRDFRKSGFL NLIKPRTKPE
     RSPTVLMTEE LSSPKAGVRS PAVDTPRKDT KPAEHNGSAD RVEEIKTPDS LEESQGEDVG
     KVDRSESKGS PQGGRRYRVQ VMGSGLLAEM KAKQEMKAKA ACSLKKLGND AISQDSSSLA
     LSSTERLDGG GAVPKVHPEN RFGLGMAEKN TKAELKVEAG SRSRSLSSRP TSPKPLLQSP
     KPSLSVRPTI PQKPRTASRP EDIPDSPSSP DSPKVALLPP VLKKVPSDKE RDSQGSPQPS
     PRTFSREVSR RSWGQQAQEC QEQKQWSSSK DGQQGSKSSD SGEEAEKEFI FV
//