ID A0A2U4C7H3_TURTR Unreviewed; 1430 AA.
AC A0A2U4C7H3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=BLM {ECO:0000313|RefSeq:XP_019801389.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019801389.1};
RN [1] {ECO:0000313|RefSeq:XP_019801389.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019801389.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR RefSeq; XP_019801389.1; XM_019945830.2.
DR STRING; 9739.ENSTTRP00000015530; -.
DR GeneID; 101340055; -.
DR InParanoid; A0A2U4C7H3; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000245320; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd18016; DEXHc_RecQ2_BLM; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR012532; BDHCT.
DR InterPro; IPR032439; BDHCT_assoc.
DR InterPro; IPR032437; BLM_N.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF08072; BDHCT; 1.
DR Pfam; PF16204; BDHCT_assoc; 1.
DR Pfam; PF16202; BLM_N; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 689..864
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 890..1037
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1225..1305
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1343..1366
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1430 AA; 160614 MW; B24D767343336997 CRC64;
MAAVPQNNLQ EQLERHSARK LNNKLSPSKP KSSGFTFKKK VSSANDVCVT SVSVAKAPVL
NDKDVTITEA FSFSEPFPHT TNQQTKINDF KNTPAGQQTK RVGSKPLLPN LSQVPQEVLC
TTQNTLLVKE SRDATFKKLE FSSSSDSLIT FSDWDDMDDF DTSGDSKAFV TPRQNHFIRV
STAQKSKKSK RNFLKAHLGK TNTVKTDLTP SSSESKQAFL TKKQKDDSEW LNSDVICIDD
DPNSEELINE DTQENHPLKT HLGEERDNCE KKKNLEEMEL HSFEKSSCVE LDEDDYDIDF
VPPSPEEGMT STSSSSLKYS SVLKDLDTSD SKDGLSISED LSKSEKMTTK QPNQETSTSY
DARQISLQQQ LIRVMDHICE LVDTIPDDKL KTLDCGNKLL QQRDIRRKLL AEADFNTSDA
SVLGSLWRCR PDSLGSSVKD MASVSPPCAF PKGDSCPTGN SVKEFTFPNL PSNSISTGEC
LLTPTPGKTG FSATTKNLFE RPLFNSHLQE SFVSSNWAET PRVEKRNESS YFPGNVLTST
AVKDQNKHTT SMNDLEREIQ ASCDIDSFDI DDFDDDDDDW ENVMHNLAAS KSSTAAYQPI
KEGRPVKSVS ERISSSAKTD CLLASTAQNK NFSESIQNYT DKSEQSLASR DLKHERFQSL
NFPHTKEMMK IFHKKFGLHN FRTNQLEAIN AALLGEDCFI LMPTGGGKSL CYQLPACVSP
GVTIVISPLR SLIIDQVQKL TSFDIPATYL TGDKTDSEAT NIYLQLSKKD PIIKLLYVTP
EKVCASNRLI STLENLYERK LLARFVIDEA HCVSQWGHDF RPDYKRMNML RQKFPSVPVM
ALTATANPRV QKDILTQLKI LRPQVFSMSF NRHNLKYYVL PKKPKKVAFD CLEWIRKHHP
HDSGIIYCLS RRECDTVADT LQKDGLAALA YHAGLSDSAR DEVQHKWINQ DGCQVICATI
AFGMGIDKPD VRFVIHASLP KSVEGYYQES GRAGRDGEIS HCLLFYTYHD VTRLKRLILM
EKDGNHHTKE THFNNLYSMV HYCENITECR RIQLLAYFGE KGFNPYFCKK YPDVSCDNCC
KTKDYKTRDV TDDVKNIVRF VQEHSSSQGT RNIKHVGPSG RFTMNMLVDI FLGSKSAKIQ
SGIFGKGSAY SRHNAERLFK KLILDRILDE DLYINANDQP IAYVMPGNKA QHVLNGHLKV
DFMETENSSS VKKQKALVTK VSQREEMVKK CLGELTEVCK SLGKVFGVHY FNIFNTVTLK
KLAESLSSDP EVLLQIDGVT EDKLEKYGAE VIPILQKYSE WTLPAEDDSS RRSPSSSRGT
GRNAPEELDE ETPISSHYFA NKTKNERKRK RMPASQRSKR RKTGFSGSKT KGGSSTCRRI
PSKTKSSSIF GPSSALHGSQ AASGVSRKLG IMAPPKPVNR PFLKPSYAFS
//
