ID A0A2U4C7T5_TURTR Unreviewed; 1642 AA.
AC A0A2U4C7T5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 1 isoform X3 {ECO:0000313|RefSeq:XP_019801421.2};
GN Name=TRPM1 {ECO:0000313|RefSeq:XP_019801421.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019801421.2};
RN [1] {ECO:0000313|RefSeq:XP_019801421.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019801421.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_019801421.2; XM_019945862.2.
DR Proteomes; UP000245320; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF13; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_019801421.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 868..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1003..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1142..1160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1477..1499
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT REGION 57..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1642 AA; 187179 MW; D1AD838D9480191A CRC64;
MAWEYLGLIS TFFLFQGQKS WIEKTFCKRE CIFVIPSTKD PNRCCCGQLT NQHIPPLPSV
TASKNGEENK QVETQPEKWS VGKHTQSYPT DSYGILEFQG GGYSNKAMYI RVSYDTKPDS
LLHLMVRDWQ LELPKLLISV HGGLQNFEMQ PKLKQVFGKG LIKAAVTTGA WIFTGGISTG
VISHVGDALK DHSSKSRGRV CAIGIAPWGI VENKEDLVGR DVTRVYQTMS NPLSKLSVLN
NSHTHFILAD NGTLGKYGAE VMLRRQLEKH ISLQKINTRL GQGVPVVGLV VEGGPNVVSM
VLEYLREEPP VPVVVCDGSG RASDILSFAH KYSEEGGIIN DSLRDQLLVT IQKTFNYNKT
QSHQLFAMIM ECMKKKELVT VFRMGSEGQQ DIEMAILTAL LKGTNASARD QLSLALAWNR
VDIARSQIFV FGPRWPPLGS LAPPTDSKAM EKEKKPPTGT TKGGRGKGKG KKKGKVKEEV
EEETDPRKLE LLNWVNALEQ AMLDALVLDR VDFVKLLIEN GVNMQHFLTI PRLEELYNTR
LGPPNTLHLL VRDVKKGNLP PDYHISLIDI GLVLEYLMGG AYRCNYTRKG FRTLYNNLFG
PKRPKALKLL GMEDDEPPAK GKKKKKKKKE EELDIDVDDP AVSRFQYPFH ELMVWAVLMK
RQKMAVFLWQ RGEESMAKAL VACKLYKSMA HESSESELVD DISQDLDNNS KDFGQLAVEL
LDQSYKHDEQ IAMKLLTYEL KNWSNSTCLK LAVAAKHRDF IAHTCSQMLL TDMWMGRLRM
RKNPGLKVIM GILLPPTILF LEFRTCDDFS YQTSKENEDG KEKEEENMDA NADTGSRKGD
EENEQKKQRS VPIGTKICEF YNAPIVKFWF YTISYLGYLL LFNYVILVRM ERWPCLQEWI
VISYIVSLAL EKIREILMSE PGKLSQKIKV WLQEYWNITD LVAISMFMIG AILRLQKQPY
MGYGRVIYCV DIIFWYIRVL DIFGVNKYLG PYVMMIGKMM IDMLYFVVIM LVVLMSFGVA
RQAILHPDEE PSWKLARNIF YMPYWMIYGE VFADQIDRKT RIHTPCGDNQ YDEEGKRLPP
CIPGAWLTPA IMACYLLVAN ILLVNLLIAV FNNTFFEVKS ISNQVWKFQR YQLIMTFHDR
PVLPPPMIIL SHVYIIIMRL SRHCRKKREG DQDEQDRGLK LFLSDEELKR LHEFEEQCVR
EHFQEKEDEQ QSSSEERIRV TCERVENMSM RLEEINEREN FMKTSLQTVD LRLSQLEELS
SRMVNALENL AGIDKSDLIQ TRSRASSECD ATYLLRQSSI NSADGYSMYR YLFNGEELYE
DTSRCMPPGT GFRKKVGSFR VKEEKDQRTH LVPERQGSLR LPPSTSTPAS PDGDRLASDN
VKSTSEPKLS PDVGISAEDD ERQADSKRGE TSSPSFSQTE VMHGQNNLDF QSTQLTVETT
KIEGTISYPL EETKVTRYYP DETFSACKAM KSRSFVYSRG RKLVGGVNKW SAAGDQTCPS
TVEQWTTEWR YQVQKIMRSQ STDIPSFGSE TALQAEHQGH FTDTEDENYV SETGPQISRL
SLAVTDRTDK ENLLSVKTHQ TLGFPSLRSK SLHGHPRNAK AIQGTLDRSR HASSVSNLAV
VSRITTEDLK VKREKDSSET EC
//
