ID A0A2U4C9I1_TURTR Unreviewed; 1742 AA.
AC A0A2U4C9I1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Unconventional myosin-Vc {ECO:0000313|RefSeq:XP_019802108.1};
GN Name=MYO5C {ECO:0000313|RefSeq:XP_019802108.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019802108.1};
RN [1] {ECO:0000313|RefSeq:XP_019802108.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019802108.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_019802108.1; XM_019946549.2.
DR STRING; 9739.ENSTTRP00000004477; -.
DR GeneID; 101327157; -.
DR InParanoid; A0A2U4C9I1; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000245320; Chromosome 2.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd15476; Myo5c_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037991; Myo5c_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 8..62
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 67..753
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1421..1697
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 632..654
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1284..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 884..1098
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1152..1186
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 161..168
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1742 AA; 202819 MW; F4F5BDD2052B8935 CRC64;
MAVAELYTQY NRVWIPDPEE VWKSAEIAKD YRVGAKVLRL LLEDGTELDY SVDPESLPPL
RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY SGIILVAMNP YKQLPIYGDA
IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR NNKNQSIIVS GESGAGKTVS ARYAMRYFAT
VSKSSTNARV EDKVLASNPI TEAVGNAKTT RNDNSSRFGK YTEISFDERN QIIGANMRTY
LLEKSRVVFQ SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG STIIEGVNDR
ANMIETQKTF TLLGFKEDFQ MDVFKILAAI LHLGNVQIIA VGNERSAVSE DGSHLEVFCE
LLGLESVRVA QWLCNRKIIT NSETVVKPMT RSQAINARDA LAKKIYAQLF DFIVERINQA
LQFSGKQHTF IGVLDIYGFE TFDANSFEQF CINYANEKLQ QQFNLHVFKL EQEEYMKEDI
PWTLIDFYDN QPVIDLIEAK MGILELLDEE CLLPHGTDEN WLQKLYNNFV NKNSLFEKPR
MSNTSFIIQH FADKVEYKCE GFLEKNRDTV YDMLVEILRA SKFHLCAHFF QENPVPSSPF
GSAITVKSAK PVIRPNNKHF RSTVGSKFRS SLYLLMETLN ATMPHYVRCI KPNDEQLPFE
FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYIEFYSRFG ILMTKQELSF SDKKEVCKVI
LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK LRLDKLRQGC VVIQKHIRGW LQRRKFLRER
RAALIIQQYF RGQQTVRKAV TATALKEAWA AIIIQKYCRA YLVRSLYQLI RVAAITIQAY
TRGFLARRRY RKMLEEHKAV ILQKYARAWL ARRRFQNIRR FVLNIQLTYR VQRLQKKLED
QNRENHGLVE KLTSLAALQA GDVEKIQKLE SELDRAATHR QNYEEKGKRY KASVEEKLAK
LQKRNSELEI QKEQIQLKLQ EKTDELKEKM DNLTKQLFDD VQKEERQRIL LEKSFELKTQ
DYEKQIRFLK EEMKALRDEK MQLQHQLEGE RVTSDGLKGE VARLSKQAKT ISEFEKEIEL
LQTQKIEVEK HVQSQKREMR EKVSEITKQL LESYDTEDVR SRLSPEDLEH LNEDGELWFA
YEGLKKATRI LESHLQSQKD CYEKEIEALN SKVVHLSQEI NHLQKLFREE NDINESIRHE
VTRLTSENMM IPDFKQQIAE LEKQKQDLEI RLNEQAENMK GKLEELSNQL NHNQEEEGTQ
RKTIGAPNEM YTKEKEKLMD KIQEMQEASE HSRKQFETES EVKSSFRQEA SRLTVEHRDL
EEVLDMKDRV IKKLQDQVKT LTKTIEKAND VHLSSGPKEY LGMLEYKRED EAKLIQNLIL
DLKPRGVVVN MIPGLPAHIL FMCVRYADSL NDANMLKSLM NSTINGIKQV VKEHLEDFEM
LSFWLSNTCH FLNCLKQYSG EEEFMKNNSL RQNKNCLNNF DLSEYRQILS DVAIRIYHQF
IIIMENNIQP IIVPGMLEYE SLQGISSLKP TGFRKRSSSI DDTDAYTMTS ILQQLSYFYS
TMCQNGLDPE IVRQAVKQLF FLIGAVTLNS LFLRKDMCSC RKGMQIRCNI SYLEEWLKDK
NLQNSLARET LEALSQAAWL LQVKKTTDSD AKEIYERCTS LSAVQIIKIL NSYTPIDDFE
KRVTPSFVRK VQALLSSRED SSHLMLDTKY LFQVTFPFTP SPHALEMIQI PSSFKLGFLN
RL
//
