ID A0A2U4C9K5_TURTR Unreviewed; 2110 AA.
AC A0A2U4C9K5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Tenascin isoform X2 {ECO:0000313|RefSeq:XP_019802046.1};
GN Name=TNC {ECO:0000313|RefSeq:XP_019802046.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019802046.1};
RN [1] {ECO:0000313|RefSeq:XP_019802046.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019802046.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
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DR RefSeq; XP_019802046.1; XM_019946487.2.
DR GeneID; 101319123; -.
DR OrthoDB; 5489847at2759; -.
DR Proteomes; UP000245320; Chromosome 6.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 13.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF1; TENASCIN; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF18720; EGF_Tenascin; 9.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 14.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 14.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 11.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 13.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2110
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015769603"
FT DOMAIN 625..717
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 805..896
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 897..986
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 987..1075
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1076..1165
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1167..1259
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1260..1348
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1349..1439
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1440..1529
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1531..1620
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1621..1710
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1711..1797
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1798..1886
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1884..2099
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
SQ SEQUENCE 2110 AA; 231474 MW; 9BF3C05AF4575E33 CRC64;
MGVVTRLLAG IFLALLALPA EGGVLKKVIR HKRQSGVNVT LPEENQPVVF NHVYNIKLPV
GSQCSVDLES ASGEKDLVPL SEPRESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDIK
ELLSRLEELE NLVSSLREQC TLGAGCCFQP AEGHLDTKPF CSGRGNFSTE GCGCVCEPGW
KGPNCSEPEC PGNCHLRGQC LDGQCVCDKG FTGEDCGQLA CPSDCNDQGK CMNGTCVCFE
GYSGVDCSQE PCPVPCSEEH GRCVDGRCVC QDGFAGEDCN EPLCLHNCRG RGSCVENECV
CDEGFTGEDC GELVCPNDCF DRGRCVNGTC YCDEGFAGED CGQLACPHAC HGRGRCDEGQ
CVCDEGFAGA DCSEKRCPSD CHDRGRCLDG HCECDDGFTG VDCGELRCPR DCSGHGRCVN
GQCVCNEGRT GEDCGQLRCP NDCHGRGRCV QGRCECELGF QGYDCSEMSC PHDCYQHGRC
LNGMCVCDDA YMGEDCRELR CPQDCSQRGR CVDGRCVCED GFAGPDCADL SCPGDCHGRG
RCVDGQCVCH EGFTGKDCGQ RRCPDDCHGQ GRCVDGQCVC HEGFTGLDCG QRSCPNDCSN
WGQCISGRCI CNEGYTGEDC SQVSPPKDLI VTEVTEETIN LAWENEMRVT EYLIVYTPTH
EDGLEMQFRV PGNQTSTTIQ ELEPGVEYLI RVFAVLENKK SIPVSARVAT YLPTPEGLKF
KSIKETSVEV EWDPVDIAFE TWEVIFRNMN KEDEEEITKS LRRPETTYRQ TGLAPGQEYE
ISLHIVKNNT RGPSLKRVTT TRLDAPSQIE VKDVTDTTAL ITWSKPLAEI DSIELTYGIK
DVPGDRTSID LTHEENQYSI GNLKPDTEYE VSLISHRADM SSSPARETFT TGLDAPRNLR
RISQTDNSIT LEWRNVKAAA DNYRIKYAPI SGGDHAEVEV PRRQQTTTKT TLTGLRPGTE
YGIGVSAVKG DKESDPATIN AATDLDAPRD LRVSETTETS LTLLWQAPLA KCDRYRLNYS
LPSGQPVEVQ LPRGTTSYVL KGLEPGQEYT ILLTAEKGRH KSKPARVQAS TDHAPEMENL
TVTEAGWDGL KLNWTTADQA YEHFVIQVQE ANRVEAAQNL TVPGSLRAAD IQGLKAATPY
RVTIYGVIRG HRTPMLSAEA STGEAPHLGE VTVSEVGWDA LKLHWTAPEG AYEQFLIQVQ
ETDTEEAAQN LTVPGGLRSV DLPGLKADTH YRVTIRGVTR DFSTTPLSVE VLTEEVPDLG
NLTVTEVSWD ALRLDWTSPD GIYEQFVIEI QAADQTQEAH SLTVPGSLCS AEIPGLRAGT
PYTITLRGEV RGRSTQPLAV EVITAELPQL GHLAVTEAGW DGLKLNWTTA DQAYEHFVIQ
VQEANRVEAA QNLTVPGSLR AADIQGLKAA TPYRVTIYGV IRGYRTPMLS AEASTAGEPE
IGNLNVSDIT PESFNLSWTA TDGAFKTFTI EIIDSNRFLE TMEYNISGAE RTAHISGLRP
NNDFIVYLSG LTPSIRTKTI SATATTEAEP EVDNLLVSDA TPDGFRLSWT ADEGVFDSFV
LKIRDTKKQS EPLEITLLAP ERTRDITGLR EATEYEIELY GISSGRRSQP VSAIATTAMG
SPKEIVFSDI TENSATVSWK APTTQVESFR VTSVPTAGGT PSVVTVAGTK TQTRLLRLLP
GVEYLVSVTA LKGFEESTPV SGMLTTALDG PSGLVTANIT DSEALATWQP AIAPVDNYVI
SYTGEREPEI TRKVSGNTVE YALTNLEPAT EYTLRIFAEK GPQKSSTITT KFMTDLDSPR
DFTATEVQSE TAVLTWRPPR ASVTGYLLVY ESVDGTTKEV VVDPDTTSYS LAELSPSTHY
MAKIQALNGP LRSKIIKTTF TTTGVLYPFP RDCSQAMLNG DTTSGVYTVY LNNNKTQKQE
VFCDMTSDGG GWIVFLRRKN GREDFYRNWK AYTAGFGDLK EEFWLGLDTL NKITAQGQYE
LRVDLRDHGQ SAYAVYDKFS VGDARTRYRL KVEGYSGTAG DSMAYHNGRS FSTFDKDTDS
AITNCALSYK GAFWYKNCHR VNLMGRYGDN NHSQGVNWFH WKGHEYSIQF AEMKLRPSNF
RNLEGRRKRA
//
