ID A0A2U4CE40_TURTR Unreviewed; 866 AA.
AC A0A2U4CE40;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Transcription factor E2F8 {ECO:0000256|ARBA:ARBA00039673};
GN Name=E2F8 {ECO:0000313|RefSeq:XP_019803686.1,
GN ECO:0000313|RefSeq:XP_019803687.1, ECO:0000313|RefSeq:XP_019803688.1,
GN ECO:0000313|RefSeq:XP_033718521.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019803687.1};
RN [1] {ECO:0000313|RefSeq:XP_019803686.1, ECO:0000313|RefSeq:XP_019803687.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019803686.1,
RC ECO:0000313|RefSeq:XP_019803687.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_019803686.1; XM_019948127.2.
DR RefSeq; XP_019803687.1; XM_019948128.2.
DR RefSeq; XP_019803688.1; XM_019948129.2.
DR RefSeq; XP_033718521.1; XM_033862630.1.
DR STRING; 9739.ENSTTRP00000005390; -.
DR GeneID; 101325793; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000245320; Chromosome 8.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF40; TRANSCRIPTION FACTOR E2F8; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 113..182
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 261..347
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 409..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 94112 MW; 886F1ECCD55840BE CRC64;
MENEKENLFF EPHKRGLVKT PLKESTAANI VLAEIQPDFG PLTTPTKPKE ISQGEPWTPT
ANLKMLISAV SPEIRYRDQK RGLFDNGNGL PEARDCLHEH LSGDEYEKSQ PSRKEKSLGL
LCHKFLARYP NYPNPAVNND ICLDEVAEEL NVERRRIYDI VNVLESLHMV SRLAKNRYTW
HGRHNLNQTL GTLKSVGEEN KYAEQIMMIK KKEYEQEFDF SKSYRIEDPI IKSNTGQNGH
PDMCFVELPG VEFRAASVNS RKDKSLRVMS QKFVMLFLVS TPQIVSLEVA AKILIGEDHV
EDLDKSKFKT KIRRLYDIAN VLSSLDLIKK VHVTEERGRK PAFKWTGPEI SPNPSGLGPV
LPFAPSDLEG RRSSKENCAK NLFSARGRPN FTRHPSLIKL VKSIESDRRK INSAPTSPIK
TNKAESSQNS VPFPSKMAQL AAICKMQLEE QSSEPRKKVK VQLARSGHCK PVAPLDTPAN
AELEMTAPSL IQPLGVVPLI PSPLPSAVPV ILPQAPSGPS YAIYLQPAQA QTMTPPQGLS
PTVCPTPSSN ATRSKGSTDT TTENAANDAP KSSASARPGS LLPGLERQGT KNRDREPAGE
RGSKRASMLE DNGSKRKFKE DLKGLENVST TLFPSGYLIP LTQCSTLGAE SILSSKESSG
TLSPNHRIYS SPIAGVIPVT SSELTAVNFP SFHVTPLKLM VSPTSVAAVP VGNSSALTSS
HPVPVQNPSS AVVNFTLQHL GLISPGMQVS ASPGPGTVPV SPRIEAVSVT PENAGTQQGR
ATKYDVSVLG QNQTNGQSVA VTGAQQPVPV TPKGSQLVAE SFFRTPGGPT KPKGSSCVDF
DGANNTSIGT LFVPQRKLEV STEDVH
//
