ID   A0A2U4CFM7_TURTR        Unreviewed;       681 AA.
AC   A0A2U4CFM7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Phosphatidylinositol-binding clathrin assembly protein isoform X2 {ECO:0000313|RefSeq:XP_019804246.1};
GN   Name=PICALM {ECO:0000313|RefSeq:XP_019804246.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019804246.1};
RN   [1] {ECO:0000313|RefSeq:XP_019804246.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019804246.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC       {ECO:0000256|ARBA:ARBA00008011}.
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DR   RefSeq; XP_019804246.1; XM_019948687.2.
DR   AlphaFoldDB; A0A2U4CFM7; -.
DR   GeneID; 101325915; -.
DR   OrthoDB; 3667239at2759; -.
DR   Proteomes; UP000245320; Chromosome 8.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   CDD; cd16985; ANTH_N_AP180; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.20.58.150; ANTH domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR014712; ANTH_dom_sf.
DR   InterPro; IPR045192; AP180-like.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR   PANTHER; PTHR22951:SF16; PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF89009; GAT-like domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT   DOMAIN          14..145
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   REGION          554..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          642..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          321..348
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        649..664
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   681 AA;  73680 MW;  A54587E6DDEEAB18 CRC64;
     MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA
     DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
     STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD
     FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF
     LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT
     TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP
     VSTSAGGIVT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVLPMSA ASQVASTWGD
     PFSATVDAVD DAIPSLNPFL TKSSGDVHPP ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH
     PSAGLNVDFE SVFGNKSTNV IVDSGGGLLK PTVASQNQSL PVAKLPPNKL VSDDLDSSLA
     NLVGNLGIGN GTTKNDVNWS QPGEKKLTGG SNWQPKVAPT TAWNAATMNG MHFPQYAPPV
     MAYPATTPTG MIGYGIPPQM GSVPVMTQPT LIYSQPVMRP PNPFGPVSGA QLSAASSPSS
     HSPHRASGKD PFAELSLEDF L
//