ID   A0A2U4CIL0_TURTR        Unreviewed;       679 AA.
AC   A0A2U4CIL0;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=DNA polymerase eta isoform X1 {ECO:0000313|RefSeq:XP_019805286.1};
GN   Name=POLH {ECO:0000313|RefSeq:XP_019805286.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019805286.1};
RN   [1] {ECO:0000313|RefSeq:XP_019805286.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019805286.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_019805286.1; XM_019949727.2.
DR   AlphaFoldDB; A0A2U4CIL0; -.
DR   GeneID; 101316946; -.
DR   OrthoDB; 118267at2759; -.
DR   Proteomes; UP000245320; Chromosome 10.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006301; P:postreplication repair; IEA:UniProt.
DR   CDD; cd01702; PolY_Pol_eta; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.1170.60; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR041298; UBZ3.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR45873; DNA POLYMERASE ETA; 1.
DR   PANTHER; PTHR45873:SF1; DNA POLYMERASE ETA; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   Pfam; PF21704; POLH-Rev1_HhH; 1.
DR   Pfam; PF18439; zf_UBZ; 1.
DR   PIRSF; PIRSF036603; DPol_eta; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR   PROSITE; PS50173; UMUC; 1.
DR   PROSITE; PS51907; ZF_UBZ3; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          9..229
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
FT   DOMAIN          595..629
FT                   /note="UBZ3-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51907"
FT   REGION          413..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          474..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..653
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   679 AA;  75187 MW;  5E6D28016E5F99DF CRC64;
     MANGQDRVIT LVDMDCFFVQ VEQRQNPHLR NKPCAVAQYK SWKGGGIISV SYEARAFGVT
     RYMWAEDAKK LCPDLLLAQV RESHGKANLT KYREASVEVM EVMSRFAVIE RASIDEAYVD
     LTSAVQERLQ KLQEEMRKQG LLQWLDSLQT DNTTSPDLQL TVGAVIVEEM RAAIERQTGF
     QCSAGISHNK VLAKLACGLN KPNRQTLVSH GSVPQLFSQV PISKIRHLGG KLGASVIETL
     GVEYMGELTQ FTESQLQSHF GEKNGSWLYA MCRGIEHDPV RPRQIPKTIA CSKNFPGKTA
     LAAREQVQWW LLQLAQELEE RLIKDRNDND RVATQLVVSI RVQGDRRLSS LRRCCALPRY
     DAHKMSHDAF ALIRNCNTSG TQTEWSPPLT MVFLCATKFS ASAPSPGTDI TIFLSSDPSS
     PSKVPITRSE DKTQENGPAV TTTKKATTSL ESFFQKAAEK QKVKEASLSS LTATTQAPIS
     NSPSKPSLPF QTSHTSGTEP FFKQKSLLLK QKQLTNVFFP PQKPQSSPKE LPNCFPTECP
     DCAPVCEKVL KLGSFKATPA EMDLAQNSLS SLASLTSKSA LEVAQKAPTT SSLLAAEDQV
     PCEKCGSLVP VWEMPEHTDY HFALDLQKSF LQPHSNPRVA PASSPQGKRN PKSPLASRNK
     RPRPEGMQTL ESFFKPLTH
//