ID A0A2U4CJ98_TURTR Unreviewed; 1345 AA.
AC A0A2U4CJ98;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Adhesion G protein-coupled receptor F5 isoform X4 {ECO:0000313|RefSeq:XP_019805528.2};
GN Name=ADGRF5 {ECO:0000313|RefSeq:XP_019805528.2};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019805528.2};
RN [1] {ECO:0000313|RefSeq:XP_019805528.2}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019805528.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_019805528.2; XM_019949969.2.
DR Proteomes; UP000245320; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF3; ADHESION G-PROTEIN COUPLED RECEPTOR F1; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00200; SEA; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_019805528.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1345
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030058378"
FT TRANSMEM 1013..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1052..1074
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1094..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1170..1198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1219..1239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1245..1268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..274
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 275..369
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 472..562
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1011..1269
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1345 AA; 149029 MW; C5EBDCCE8DB5A7CA CRC64;
MKSPRRTTLC FMIIVIFSSQ ATLNLNLESI VYPSLLHEHE LAGADPIRQK RAAAVSSPAA
QEFTVNVEVS FEDASFLEPS KAYLKNLSFP VQGDDADPAT SILSIEVTTV CRPTGNEVWC
SCEKGYKWPQ EKCLHNLTCQ GRDGSPSGHH CSLLKGLPPK GPFCQLQGAD ITLRMSVRLN
VGFQEELKNS SSALYRSYKT DLETAFWKGY SILPGFKLVT VTEFRPGSVV VVYEVTTTAA
SPELMRKANE QVTQNLRQTY KMDSSSFQVT YSNETKFSIT PEIIFEGDTV TLMCENEVLS
SNVSWQHVDT GFDIQNSSRF SIYTYVLNNM TSVSRLTIYN ITQDDAGEYI CKLTLDIFEY
GSRKKIDVTS IQIWANEDMK VMCDNSPVSL NCCSEMTVNW SQVEWKQQGS VSIPGSPETD
ADPRCSRYTL TANGTQCPSR LSGTTVIYTC EFISAHGARG SKDIKVTFIS VANLKITPDP
ISVSEGQSFS IKCISDMSNY DEVYWNTSAG IKIYKRFYTT RRYPDGAESV LTVKTSTREW
NGTYHCIFRY KNSYSVMAKD VTVHPLPLQP NIMVDPLEAA IPCTSSRHIK CCIEEDRDYK
VIFQAGSSSF PAAKEVNGKQ VCYKHHFVAN SISCPENMNV FCHITNTANN SVRSPSMKLN
LVPGENVTCQ DPIIGVGEPG KVIQKLCQFS NVPRIPGSPI GGIITYRCVG SQWKVKKNNC
ISAPINTLLQ LAEALMKSPS QDEKLPSYLK NLSISTNQVK LEVKSFPGSL GAIINILDLL
STVPTQVNSE MMMHVLSTVN VILGKPILNT WMMSQQQKTN QSSQLLDSLE RFSRALRSED
STISQPNVQM KSMVIKSGHP KSYTQSFVFL DSELWGNVTI NECQLEHLQP DSFIVTVAFP
TLKTILAQDV PGKTFANSLV MTTTVSHNLT APSPFRISMT FKNNNPSGGV PRCVFWNFNL
ANHTGGWDSS GCYVKEVTED SVSCSCDHLT SFSILMSPDS PDPDSLLKIL LDIISYIGLC
FSILSLAACL AVEAVVWKSV TKNRTSSMRH ICIVNIAASL LVADVWFIVA AAVHNYRYPL
NQTACVAATF FVHFSYLSVF FWMLTLGLML FYRLVFILHD TSKSIQKAIA FSLGYGCPLV
ISVITVGATQ PREVYTRKNA CWLNWEDTKA LLAFVIPALI IVVVNVTITV VVITKILRPS
IGDKPSRQEK SSLFQITKSL GVLTPLLGLT WGFGLATVFQ GSNAVFHIVF TLLNAFQGLF
ILLFGCLWDQ KVQEALLNKF SLSRWSSQHS KSTSLGSSTP VFSMSSPISR RFNNLFGKTG
TYNVSTPEIT SSSLENTSSA YSLLN
//
