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Database: UniProt
Entry: A0A2U4CLM6_TURTR
LinkDB: A0A2U4CLM6_TURTR
Original site: A0A2U4CLM6_TURTR 
ID   A0A2U4CLM6_TURTR        Unreviewed;       628 AA.
AC   A0A2U4CLM6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 {ECO:0000256|ARBA:ARBA00020285};
GN   Name=SAMHD1 {ECO:0000313|RefSeq:XP_019806351.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019806351.1};
RN   [1] {ECO:0000313|RefSeq:XP_019806351.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019806351.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC         deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC         ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC         Evidence={ECO:0000256|ARBA:ARBA00001432};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC   -!- SIMILARITY: Belongs to the SAMHD1 family.
CC       {ECO:0000256|ARBA:ARBA00005776}.
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DR   RefSeq; XP_019806351.1; XM_019950792.2.
DR   AlphaFoldDB; A0A2U4CLM6; -.
DR   STRING; 9739.ENSTTRP00000001812; -.
DR   GeneID; 101321259; -.
DR   InParanoid; A0A2U4CLM6; -.
DR   OrthoDB; 5474479at2759; -.
DR   Proteomes; UP000245320; Chromosome 15.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd09508; SAM_HD; 1.
DR   Gene3D; 3.30.70.2760; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR   PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR   Pfam; PF01966; HD; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Allosteric enzyme {ECO:0000256|ARBA:ARBA00022533};
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT   DOMAIN          45..110
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          164..317
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  72368 MW;  5300739F755408B3 CRC64;
     MQSADSQKPP KRPRRDGSPR TPPNTPPADT ERSPSPDLHP DHRTWGPEQV CSFLRDCGFS
     DSGLLERCRE KKITGSILPF LDESLLEDLG ISSYGKRIKL LNNIQQLDQT HVYTMKVIND
     PIHGHIEFHP LLIRIIDTPQ FQRLRYIKQL GGGYYVFPGA SHNRFEHSLG VGYLAGRLVR
     ELSEKQPELQ ISERDMLCVQ IAGLCHDLGH GPFSHMFDGR FIPLARPDVK WTHEQGSVMM
     FEHLVNSNGL RDVMEQYGLI PEEDIWFIKE QITGPPESPI KDSSKWLYKG RPKEKSFLYE
     IVANKRNGID VDKWDYFARD CHHLGIQNNF DYKRFIKFAR VCEVDDRKHI CTREKEVGNL
     YDMFHTRNSL HRRAYQHKVG NIIDTMITDA FLEADPYIEI TGSEGKKYHI STAIDDMEAF
     TKLTDNIFLE ILYSADPKLD AARAILKKIE CRNLYKFVGE TQPIGQIKIK RENYESLPKG
     VASAKPSDMV LEPELKAEDF IVDVINMDYG MEDKNPIDHV RFYCKSEPSQ AIMITKNQVS
     QFLPEVFAEQ LIRVYCKKTD KRSLYAAQQH FVQWCLINDF TKPQDGDIVA PLITPRKSEW
     NYTDSAQSPA HTREASKCRA QLFRDGSV
//
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