ID A0A2U4CLM6_TURTR Unreviewed; 628 AA.
AC A0A2U4CLM6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 {ECO:0000256|ARBA:ARBA00020285};
GN Name=SAMHD1 {ECO:0000313|RefSeq:XP_019806351.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019806351.1};
RN [1] {ECO:0000313|RefSeq:XP_019806351.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019806351.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC Evidence={ECO:0000256|ARBA:ARBA00001432};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the SAMHD1 family.
CC {ECO:0000256|ARBA:ARBA00005776}.
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DR RefSeq; XP_019806351.1; XM_019950792.2.
DR AlphaFoldDB; A0A2U4CLM6; -.
DR STRING; 9739.ENSTTRP00000001812; -.
DR GeneID; 101321259; -.
DR InParanoid; A0A2U4CLM6; -.
DR OrthoDB; 5474479at2759; -.
DR Proteomes; UP000245320; Chromosome 15.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd09508; SAM_HD; 1.
DR Gene3D; 3.30.70.2760; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Allosteric enzyme {ECO:0000256|ARBA:ARBA00022533};
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 45..110
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 164..317
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 72368 MW; 5300739F755408B3 CRC64;
MQSADSQKPP KRPRRDGSPR TPPNTPPADT ERSPSPDLHP DHRTWGPEQV CSFLRDCGFS
DSGLLERCRE KKITGSILPF LDESLLEDLG ISSYGKRIKL LNNIQQLDQT HVYTMKVIND
PIHGHIEFHP LLIRIIDTPQ FQRLRYIKQL GGGYYVFPGA SHNRFEHSLG VGYLAGRLVR
ELSEKQPELQ ISERDMLCVQ IAGLCHDLGH GPFSHMFDGR FIPLARPDVK WTHEQGSVMM
FEHLVNSNGL RDVMEQYGLI PEEDIWFIKE QITGPPESPI KDSSKWLYKG RPKEKSFLYE
IVANKRNGID VDKWDYFARD CHHLGIQNNF DYKRFIKFAR VCEVDDRKHI CTREKEVGNL
YDMFHTRNSL HRRAYQHKVG NIIDTMITDA FLEADPYIEI TGSEGKKYHI STAIDDMEAF
TKLTDNIFLE ILYSADPKLD AARAILKKIE CRNLYKFVGE TQPIGQIKIK RENYESLPKG
VASAKPSDMV LEPELKAEDF IVDVINMDYG MEDKNPIDHV RFYCKSEPSQ AIMITKNQVS
QFLPEVFAEQ LIRVYCKKTD KRSLYAAQQH FVQWCLINDF TKPQDGDIVA PLITPRKSEW
NYTDSAQSPA HTREASKCRA QLFRDGSV
//