ID   A0A2U4CMC9_TURTR        Unreviewed;       754 AA.
AC   A0A2U4CMC9;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Cadherin-12 isoform X2 {ECO:0000313|RefSeq:XP_019806594.1};
GN   Name=CDH12 {ECO:0000313|RefSeq:XP_019806594.1};
OS   Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Delphinidae; Tursiops.
OX   NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019806594.1};
RN   [1] {ECO:0000313|RefSeq:XP_019806594.1}
RP   IDENTIFICATION.
RC   TISSUE=Spleen {ECO:0000313|RefSeq:XP_019806594.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   RefSeq; XP_019806594.1; XM_019951035.2.
DR   AlphaFoldDB; A0A2U4CMC9; -.
DR   GeneID; 101323926; -.
DR   OrthoDB; 3667774at2759; -.
DR   Proteomes; UP000245320; Chromosome 3.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 4.
DR   Gene3D; 2.60.40.60; Cadherins; 5.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027:SF96; CADHERIN-12; 1.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 1.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..754
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015682257"
FT   TRANSMEM        566..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          80..160
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          185..229
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          230..344
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          345..449
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          449..567
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   754 AA;  83970 MW;  8FE0D1A566759933 CRC64;
     MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGWRSHFQ RVKRGWVWNQ
     FFVLEEYMGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT VFTIDETTGD IHAIRSLDRE
     EKPFYTLRAQ AVDIETRKPL EPESEFIIKV QDINDNEPKF LDGPYIASVP EMSPVGVIRT
     ALPNMDREVK EQYQVLIQAK DMGGQLGGLA GTTIVNITLT DVNDNPPRFP KSIFHLKVPE
     SSPIGSAIGR IRAVDPDFGQ NAEIEYSIVP GDGGNLFDIV TDENTQEGVL KLKKPLDFET
     KKAYTFKVEA SNLHLDHRFH SAGPFKDTAT VKISVLDVGE PPVFSKPLYT MEVYEDTPVG
     TIIGAVTAQD LDVGSSAVRY FIDWKSDGDS YFTIDATEGT ISTSELLDRE STAQYNFSII
     ASKVSNPLLT SRVNILINVL DVNEFPPEIS VPYETAVCEN AKPGQIIQIV SAADRDLSPA
     GQQFSFKLSP EAAIKPNFTV RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPVQS
     STNTMTIRVC RCDSDGTILS CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ
     KKKDTLMTSK EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEDNKIR RDIKPDSLCL
     PRQRPPVEDN ADIRDFINQR LQENDMDPTA PPYDSLATYA YEGNGSVADS LSSIESLTME
     ADQDYTYLTD WGPHFKVLAD MFGEEESYKT DKVT
//