ID A0A2U4CNN0_TURTR Unreviewed; 1235 AA.
AC A0A2U4CNN0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=SAM and SH3 domain-containing protein 1 isoform X2 {ECO:0000313|RefSeq:XP_019806980.1};
GN Name=SASH1 {ECO:0000313|RefSeq:XP_019806980.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019806980.1};
RN [1] {ECO:0000313|RefSeq:XP_019806980.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019806980.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019806980.1; XM_019951421.2.
DR AlphaFoldDB; A0A2U4CNN0; -.
DR STRING; 9739.ENSTTRP00000014486; -.
DR GeneID; 101315895; -.
DR OrthoDB; 5403637at2759; -.
DR Proteomes; UP000245320; Chromosome 12.
DR CDD; cd09559; SAM_SASH1_repeat1; 1.
DR CDD; cd09492; SAM_SASH1_repeat2; 1.
DR CDD; cd11967; SH3_SASH1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037627; SASH1_SAM_repeat1.
DR InterPro; IPR037630; SASH1_SAM_repeat2.
DR InterPro; IPR035720; SASH1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR021090; SPIDER.
DR PANTHER; PTHR12301:SF3; SAM AND SH3 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12301; SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF12485; SLY; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 545..606
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 624..688
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1165..1229
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..965
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1007
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1048
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1235 AA; 135254 MW; 3D20103A84CAD54B CRC64;
MEEDAGAAGA APEPEAEPAP EPEAGAGLSE AFSRLWTDVM GILDGSLGNI DDLAQQYADY
YNTCFSDVCE RMEELRKRRV SQDLDVEKPE ASPTSLQLRS QIEESLGFSS TVSTPEVERK
NPLHKSHSED SSVGKGDWKK KNKYFWQNFR KNQKGIMRQT SKGEDVGYVA SEITMSDEER
IQLMMMVKEK MISIEEALAR LKEYEAQHRQ SAALDPADWP DGSYPPFEGS SNCNSREQSD
DETEESVKFK RLHKLVNSTR RVRKKLIRVE EMKKPSPEGG EEQVFESSPV PDERSALYSG
VHKKPFFFDA SPEKPPEDDS DSLTTSPSSS SLDTWGAGRK LVKTFSKGES RGLIKPPKKM
GTFFSYPEDD KAQKVSRSLT EGEMKKGLGS LSHGRTCSFG GFDLTNRSLH IGSNNSDPLG
KEGDFVYKEV IKSPTASRIS LGKKVKSVKE TMRKRMSKKY SSSVSEQDSG LDGMPGSPPS
SQPDSEHMDK PKLKAGGSVE SLRSSLSGQS SMSGQTVSTT DSSTSNRESV KSEDGDDEEP
PYRGPFCGRA RVHTDFTPSP YDTDSLKLKK GDIIDIISKP PMGTWMGLLN NKVGTFKFIY
VDVLNEEEEK PKRPTRRRRK GRPPQPKSVE DLLDRINLKE HMPTFLFNGY EDLDTFKLLE
EEDLDELNIR DPEHRAVLLT AVELLQEYDS NSDQSGSQEK LLVDSQGLSG CSPRDSGCYE
SSENLENGKS RKTSPSARSS AESSVKSFNR NQLGSYPTLP LTKPVDALKP GGEGRLGSGL
TPHTSKHCDP PCVTDLNKNR RSLPVSICRS CETLEGPQTV ETWPRSHSLD DLQGEPEKDV
PGEVTEPSPQ IVPKVPQKTA PSITKVQSPN LDSAVDNALL LTQSKRFSEP QKTTTKKLDG
PMAAFSQGTS PPPCLPKTYD AQPPAVKHGL TRTPLEGHRK GLDFEGTHHP PGTKEGVDAE
QRGPEARSQA RPPTQPPPVP AKKSRERLAN GLPPVPPGPP SAPGPDAPSL PLKKGSPGGP
SDCPPPPVAR PPPVPEPGSP PSARPPPWLS ELPESASLQE HGVRLGPALA RKVSCTRGVD
LEMLTEKKLR AEGIDLTEEP YSDKHGRCGI PEALVQRYAE DLDQPERDVA TNMDQIRVKL
LRKQHRMAIP SGGLTEICRK PLSPGCISSV SDWLVSIGLP MYASALTEAG FSTLGQVPSL
SHTCLQEAGI TEERHISKLV SAARLFKLPP GPEAM
//
