ID A0A2U4CR45_TURTR Unreviewed; 1109 AA.
AC A0A2U4CR45;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X8 {ECO:0000313|RefSeq:XP_019807926.1};
GN Name=PAN2 {ECO:0000313|RefSeq:XP_019807926.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019807926.1};
RN [1] {ECO:0000313|RefSeq:XP_019807926.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019807926.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019807926.1; XM_019952367.2.
DR AlphaFoldDB; A0A2U4CR45; -.
DR GeneID; 101324369; -.
DR OrthoDB; 9810at2759; -.
DR Proteomes; UP000245320; Chromosome 11.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd02672; Peptidase_C19P; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR048841; PAN2_N.
DR InterPro; IPR028881; PAN2_UCH_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR15728; DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR PANTHER; PTHR15728:SF0; PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR Pfam; PF20770; PAN2_N; 1.
DR Pfam; PF13423; UCH_1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 531..938
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 1109 AA; 124369 MW; 9B82063C51D99DD5 CRC64;
MNFEVLDPGL AEYAPAMHST LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR
QIQSLENGIL FLTKNNLKYM ARGGLIIFDY LLDESEDMHS LLLTDSSTLL VGGLQNHILE
IDLNTVQETQ KYAVETPGVT IMRQTNRFFF CGHTSGRVSL RDLRTFKVEH EFDAFSGSLS
DFDVHGNLLA TCGFSSRLTG LACDRFLKVY DLRMMRAITP LQVHVDPAFL RFIPTYTSRL
AIISQSGQCQ FCEPTGLANP ADIFHVNPVG PLLMTFDVSA SKQALAFGDS EGCVHLWTDS
PEPSFNPYSR ETEFALPCLV DSLPPLDWSQ DLLPLSLIPV PLTTDTLLSD WPAANSAPAP
RRAPPVDAEI LRTMKKVGFI GYAPNPRTRL RNQASSSCSE QGLLFVAIPY RLKESDSEFD
SFSQVTESPI GREEEPHRHM VSKKYRKVTI KYSKLGLEDF DFKHYNKTLF AGLEPHIPNA
YCNCMIQVLY FLEPVRCLIQ NHLCQKEFCL ACELGFLFHM LDLSRGDPCQ GSNFLRAFRT
IPEASALGLI LADSDEASGK GNLARLIQRW NRFILTQLHQ DLQELEVPQA YRGAGGSSFC
SSGDSVIGQL FSCEMENCSL CRCGSETVRA SSTLLFTLSY PEGSNTDKTG KNCDFAQVLK
RSICLEQNTQ AWCDNCEKYQ PTIQTRNICH LPDILVINCE VNSLKEADFW RMQAEVAFKI
AIKKHGGEIS KNKEFALADW KELGSPEGML MCPSIEELKN VWLPFSIRMK MTKNKGLDVC
NWTDGDEMQW GPARAEEEHG VYVYDLMATV VHILDSRTGG SLVAHIKVGE TYHQRKEGVT
HQQWYLFNDF LIEPIDKHEA VQFDMNWKVP AILYYIKRNL NSKYNLNIKN PIEASVLLAE
ASLARKQRKT HTTFIPLMLN EMPQVGDLVG LDAEFVTLNE EEAELRSDGT KSTIKPSQMS
VARITCVRGQ GPNEGIPFID DYISTQEQVV DYLTQYSGIK PGDLDAKISS KHLTTLKSTY
LKLRFLIDIG VKFVGHGLQK DFRVINLMT
//
