ID A0A2U4CRC2_TURTR Unreviewed; 1419 AA.
AC A0A2U4CRC2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ras GTPase-activating protein nGAP isoform X2 {ECO:0000313|RefSeq:XP_019808004.1};
GN Name=RASAL2 {ECO:0000313|RefSeq:XP_019808004.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019808004.1};
RN [1] {ECO:0000313|RefSeq:XP_019808004.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019808004.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019808004.1; XM_019952445.2.
DR GeneID; 101317971; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000245320; Chromosome 1.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 207..438
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 429..547
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 607..799
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 189..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1396..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1246..1332
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 248..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1419 AA; 160365 MW; 47F58D7C25F4D527 CRC64;
MESWKMSIFR RQTSPCPPSY RRSLSEPDYA HSEIGTSVKS YPWCGPMKSK RKKNEQAVSN
LGKPLGAYQW QTHPSFRWKG DKREQLQNNK GGLDEPQQEV LPKMVGDNVS SSANEVLGTS
VEKQNLVNTR SLRVPFSRSL SEPEHRCSIR FVRRWPTSVG SMESEQQGYF IRGIFSTLSS
GFSRMLSLKG ESTNEPVRED VKGPPTHRLS CGQSPYTDTT TWERKYCILT DSQLVLLNKE
KEIPVEGGQD QQTDSTKGRC LRRTVSVPSE GQFPEYPPEG AAKLEVPAER SPRRRSISGT
STSEKPNSMD TANTSPFKVP GFFSKRLKGS IKRTKSQSKL DRNTSFRLPS LRNTDDRSRG
LPKLKESRSH ESLLSPCSAV ECLDLGRGEP VSVKPLHSSI LGQDFCFEVT YLSGSKCFSC
NSASERDKWM ENLRRTVQPN KDNCRRAENV LRLWIIEAKD LAPKKKYFCE LCLDDTLFAR
TTSKTKADNI FWGEHFEFYS LPPLHSITVH IYKDVEKKKK KDKNNYVGLV NIPTASVTGR
QFVEKWYPVS TPTPNKGKTG GPSIRIKSRF QTITILPMEQ YKEFAEFVTS NYTMLCSVLE
PVISVRNKEE LACALVHILQ STGRAKDFLT DLVMSEVDRC GEHDVLIFRE NTIATKSIEE
YLKLVGQQYL HDALGEFIKA LYESDENCEV DPSKCSSSEL IDHQSNLKMC CELAFCKIIN
SYCVFPRELK EVFASWKQQC LNRSKQDISE RLISASLFLR FLCPAIMSPS LFNLMQEYPD
DRTSRTLTLI AKVIQNLANF AKFGNKEEYM AFMNDFLEHE WGGMKRFLLE ISNPDTISNT
PGFDGYIDLG RELSVLHSLL WEVVSQLDKG ENSFLQATVA KLGPLPRVLA DITKSLTNPT
PIQQQLRRFT EHNSSPNVSG SLSSGLQKIF EDPTDSDLHK LKSPSQDNTD SYFRGKTLLL
VQQASSQSMT YSEKDEKENS LPNGRSISLM DLQDTHAAQV EHASVMLDMP MRLTGSQLSI
TQVASIKQLR ETQSTPQSAP QVRRPLHPAL NQPGSLQPLS FQNPVYHLNN PIPAMPKASV
DSSLENLSTA SSRSQSNSED FKLSGPSNSS MEDFTKRSTQ SEDFSRRHTV SDRHIPLALP
RQNSTGQAQI RKMDQAGLGA RAKAPPSLPH SASLRSTGSM SLASAALVAE PVQNGSRSRQ
QSSSSRESPV PKVRAIQRQQ TQQVQSPVDS ATMSPVERTA AWVLNNGQYE EDVEETEQNQ
DEAKHAEKYE QEITKLKERL RVSSRRLEEY ERRLLVQEQQ MQKLLLEYKA RLEDSEERLR
RQQEEKDSQM KSIISRLMAV EEELKKDHAE MQAVIDAKQK IIDAQEKRIV SLDSANTRLM
SALTQVKERY SMQVRNGISP TNPTKLSITE NGEFKNSSC
//
