ID A0A2U4CRN4_TURTR Unreviewed; 1184 AA.
AC A0A2U4CRN4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Ras GTPase-activating protein nGAP isoform X8 {ECO:0000313|RefSeq:XP_019808010.1};
GN Name=RASAL2 {ECO:0000313|RefSeq:XP_019808010.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_019808010.1};
RN [1] {ECO:0000313|RefSeq:XP_019808010.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_019808010.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_019808010.1; XM_019952451.2.
DR AlphaFoldDB; A0A2U4CRN4; -.
DR GeneID; 101317971; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000245320; Chromosome 1.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320}.
FT DOMAIN 152..270
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 330..522
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 969..1055
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 17..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1184 AA; 133951 MW; DC6271D643ECC7EF CRC64;
MGSSCDKEVP AERSPRRRSI SGTSTSEKPN SMDTANTSPF KVPGFFSKRL KGSIKRTKSQ
SKLDRNTSFR LPSLRNTDDR SRGLPKLKES RSHESLLSPC SAVECLDLGR GEPVSVKPLH
SSILGQDFCF EVTYLSGSKC FSCNSASERD KWMENLRRTV QPNKDNCRRA ENVLRLWIIE
AKDLAPKKKY FCELCLDDTL FARTTSKTKA DNIFWGEHFE FYSLPPLHSI TVHIYKDVEK
KKKKDKNNYV GLVNIPTASV TGRQFVEKWY PVSTPTPNKG KTGGPSIRIK SRFQTITILP
MEQYKEFAEF VTSNYTMLCS VLEPVISVRN KEELACALVH ILQSTGRAKD FLTDLVMSEV
DRCGEHDVLI FRENTIATKS IEEYLKLVGQ QYLHDALGEF IKALYESDEN CEVDPSKCSS
SELIDHQSNL KMCCELAFCK IINSYCVFPR ELKEVFASWK QQCLNRSKQD ISERLISASL
FLRFLCPAIM SPSLFNLMQE YPDDRTSRTL TLIAKVIQNL ANFAKFGNKE EYMAFMNDFL
EHEWGGMKRF LLEISNPDTI SNTPGFDGYI DLGRELSVLH SLLWEVVSQL DKGENSFLQA
TVAKLGPLPR VLADITKSLT NPTPIQQQLR RFTEHNSSPN VSGSLSSGLQ KIFEDPTDSD
LHKLKSPSQD NTDSYFRGKT LLLVQQASSQ SMTYSEKDEK ENSLPNGRSI SLMDLQDTHA
AQVEHASVML DMPMRLTGSQ LSITQVASIK QLRETQSTPQ SAPQVRRPLH PALNQPGSLQ
PLSFQNPVYH LNNPIPAMPK ASVDSSLENL STASSRSQSN SEDFKLSGPS NSSMEDFTKR
STQSEDFSRR HTVSDRHIPL ALPRQNSTGQ AQIRKMDQAG LGARAKAPPS LPHSASLRST
GSMSLASAAL VAEPVQNGSR SRQQSSSSRE SPVPKVRAIQ RQQTQQVQSP VDSATMSPVE
RTAAWVLNNG QYEEDVEETE QNQDEAKHAE KYEQEITKLK ERLRVSSRRL EEYERRLLVQ
EQQMQKLLLE YKARLEDSEE RLRRQQEEKD SQMKSIISRL MAVEEELKKD HAEMQAVIDA
KQKIIDAQEK RIVSLDSANT RLMSALTQVK ERYSMQVRNG ISPTNPTKLS ITENGKHANT
EIQTKQFIPL INEDWFWMDS YLIWGYTVPE DTDKSCCIKT GLSE
//
