ID A0A2U7U8N8_9VIRU Unreviewed; 206 AA.
AC A0A2U7U8N8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Sulfhydryl oxidase {ECO:0000256|RuleBase:RU371123};
DE EC=1.8.3.2 {ECO:0000256|RuleBase:RU371123};
GN ORFNames=pqer_cds_375 {ECO:0000313|EMBL:AVK74797.1};
OS Pandoravirus quercus.
OC Viruses; Pandoravirus.
OX NCBI_TaxID=2107709 {ECO:0000313|EMBL:AVK74797.1};
RN [1] {ECO:0000313|EMBL:AVK74797.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Quercus {ECO:0000313|EMBL:AVK74797.1};
RX PubMed=29891839; DOI=10.1038/s41467-018-04698-4;
RA Legendre M., Fabre E., Poirot O., Jeudy S., Lartigue A., Alempic J.M.,
RA Beucher L., Philippe N., Bertaux L., Christo-Foroux E., Labadie K.,
RA Coute Y., Abergel C., Claverie J.M.;
RT "Diversity and evolution of the emerging Pandoraviridae family.";
RL Nat. Commun. 9:2285-2285(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR';
CC Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000999,
CC ECO:0000256|RuleBase:RU371123};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU371123};
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DR EMBL; MG011689; AVK74797.1; -; Genomic_DNA.
DR Proteomes; UP000248852; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016971; F:flavin-dependent sulfhydryl oxidase activity; IEA:InterPro.
DR Gene3D; 1.20.120.310; ERV/ALR sulfhydryl oxidase domain; 1.
DR InterPro; IPR039799; ALR/ERV.
DR InterPro; IPR036774; ERV/ALR_sulphydryl_oxid_sf.
DR InterPro; IPR017905; ERV/ALR_sulphydryl_oxidase.
DR PANTHER; PTHR12645; ALR/ERV; 1.
DR PANTHER; PTHR12645:SF0; FAD-LINKED SULFHYDRYL OXIDASE ALR; 1.
DR Pfam; PF04777; Evr1_Alr; 1.
DR SUPFAM; SSF69000; FAD-dependent thiol oxidase; 1.
DR PROSITE; PS51324; ERV_ALR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU371123};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU371123}; Membrane {ECO:0000256|RuleBase:RU371123};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU371123};
KW Reference proteome {ECO:0000313|Proteomes:UP000248852};
KW Transmembrane {ECO:0000256|RuleBase:RU371123};
KW Transmembrane helix {ECO:0000256|RuleBase:RU371123}.
FT TRANSMEM 141..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU371123"
FT DOMAIN 13..117
FT /note="ERV/ALR sulfhydryl oxidase"
FT /evidence="ECO:0000259|PROSITE:PS51324"
SQ SEQUENCE 206 AA; 21893 MW; 9955271914CA3244 CRC64;
MTPTLQPTTP SDGGSDVMHL VGPPMWETLH YAAFQCPEPF DERVSSALIG LVRGYVVLLP
CAECRGHFAA LLDAHPPEVA ARSGRQAFAR WTVDAHNAVN ARLGKPLFTY DQATRRYARG
NLHCRDPGGG PRAARRSSSP AVAFAVVLAA VALAAAVLAG VWFYLSARDG AGRLSPDPAV
APAPSDTCAP APCMPKWPRW GPTDAR
//
