ID A0A2U8E648_9BACT Unreviewed; 749 AA.
AC A0A2U8E648;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN Name=feoB {ECO:0000313|EMBL:AWI10002.1};
GN ORFNames=CKA38_12735 {ECO:0000313|EMBL:AWI10002.1};
OS Ereboglobus luteus.
OC Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae;
OC Ereboglobus.
OX NCBI_TaxID=1796921 {ECO:0000313|EMBL:AWI10002.1, ECO:0000313|Proteomes:UP000244896};
RN [1] {ECO:0000313|EMBL:AWI10002.1, ECO:0000313|Proteomes:UP000244896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ho45 {ECO:0000313|EMBL:AWI10002.1,
RC ECO:0000313|Proteomes:UP000244896};
RX PubMed=29295750; DOI=10.1016/j.syapm.2017.10.005;
RA Tegtmeier D., Belitz A., Radek R., Heimerl T., Brune A.;
RT "Ereboglobus luteus gen. nov. sp. nov. from cockroach guts, and new
RT insights into the oxygen relationship of the genera Opitutus and
RT Didymococcus (Verrucomicrobia: Opitutaceae).";
RL Syst. Appl. Microbiol. 41:101-112(2018).
CC -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC {ECO:0000256|RuleBase:RU362098}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU362098}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU362098}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000256|RuleBase:RU362098}.
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DR EMBL; CP023004; AWI10002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U8E648; -.
DR OrthoDB; 9809127at2; -.
DR Proteomes; UP000244896; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01879; FeoB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR011640; Fe2_transport_prot_B_C.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00437; feoB; 1.
DR PANTHER; PTHR43185; FERROUS IRON TRANSPORT PROTEIN B; 1.
DR PANTHER; PTHR43185:SF2; FERROUS IRON TRANSPORT PROTEIN B; 1.
DR Pfam; PF07664; FeoB_C; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR603373-
KW 1}; Ion transport {ECO:0000256|RuleBase:RU362098};
KW Iron {ECO:0000256|RuleBase:RU362098};
KW Iron transport {ECO:0000256|RuleBase:RU362098};
KW Magnesium {ECO:0000256|PIRSR:PIRSR603373-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362098};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR603373-2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR603373-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000244896};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362098};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362098};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362098}.
FT TRANSMEM 338..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 583..602
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 622..638
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 645..662
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 682..700
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 721..744
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT DOMAIN 32..194
FT /note="FeoB-type G"
FT /evidence="ECO:0000259|PROSITE:PS51711"
FT BINDING 39..46
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT BINDING 50
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT BINDING 51
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT BINDING 53
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT BINDING 54
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT BINDING 85..88
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT BINDING 145..148
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
SQ SEQUENCE 749 AA; 80642 MW; A090B934E7BBBF02 CRC64;
MSDACPPSSC STCPSAPREG LERLGVRIDQ WDCVIALAGN PNTGKSTVFN SLTGLRQHTG
NWPGKTIARA EGGFSYQGKR YKIVDLPGTY SLRSASPDET VAREFILFGQ PDVSVIVADA
SSLERNLNLV LQVLQITDKA VLCLNLMDEA RANNLVIDAR RLSADLGIPV VPCAARRGEG
IDKLLAEIHA VATGAVVCKP RRLQLDVPGL REALPLIVER LKKTFPALAH PDWIALRLLE
GDRSIADLVR NGRIGTLAGD HAATANTGSE SAANSPAADN PEGVSIVETA LHMRWKLPSN
YRDRLTEAIY AESSRIVSRS VARKGASRRV DLQNKLDALL TGPWTGFPIM GLAFAVVLWI
TISGANYPSE LLNTLLLGKI YPFLHDLAHA HLWPWLAGLL IDGVYLAAAW VISVMLPPMA
IFFPLFTILE DFGYLPRVAF NLDRLFQRVG AHGKQSLTMA MGYGCNAAGI IAARVIDSPR
ERLIAIITNN FAICNGRWPA QILIATIFLG ALAPAALAGV TATLAVFLIA VLGFALTLLT
SWALSRTVLR GEASTFSLEL PPYRPPNILR TLYTSLIDRT LFVLWRAIVF AAPAGAVIWL
VANVTIGGTS LAGWIVGGLD PLAWFIGLNG VILLAYIIAI PANEIVIPTV LMLTVLLTGH
VVPGSEAGVI FETDNASVKT LLTQGGWTLL TGINLMLFSL CHNPCSTTIY TIYKETRSAK
WTALATFMPI AIGVALCSLV AFVWRMAAG
//
