ID A0A2U8FSP7_9BURK Unreviewed; 1061 AA.
AC A0A2U8FSP7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=CusA/CzcA family heavy metal efflux RND transporter {ECO:0000313|EMBL:AWI53424.1};
GN ORFNames=DEH84_08245 {ECO:0000313|EMBL:AWI53424.1};
OS Aquabacterium olei.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Aquabacterium.
OX NCBI_TaxID=1296669 {ECO:0000313|EMBL:AWI53424.1, ECO:0000313|Proteomes:UP000244892};
RN [1] {ECO:0000313|EMBL:AWI53424.1, ECO:0000313|Proteomes:UP000244892}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 110486 {ECO:0000313|EMBL:AWI53424.1,
RC ECO:0000313|Proteomes:UP000244892};
RA Tang B., Chang J., Zhang L., Yang H.;
RT "complete genome sequence of Aquabacterium olei NBRC 110486.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; CP029210; AWI53424.1; -; Genomic_DNA.
DR RefSeq; WP_058085855.1; NZ_CP029210.1.
DR AlphaFoldDB; A0A2U8FSP7; -.
DR KEGG; aon:DEH84_08245; -.
DR OrthoDB; 9798415at2; -.
DR Proteomes; UP000244892; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000244892};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 906..925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..956
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 977..997
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1009..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1041..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 115102 MW; CAF0D448686B1DE4 CRC64;
MFERIIRFAI EQRWLVLLAV FGMAALGVFS YQKLPIDAVP DITNVQVQIN TQTPGYSPLE
TEQRVTYPLE TVMAGLPGLE QTRSLSRYGL SQITVIFKDG TDLYFARQLV NERIQEAKAR
LPEGVTPAMG PISTGLGEIY MWTVEAKDGA KKPDGTPYTP TDLREIQDWI IKPQLRNVTG
VTEINSIGGY AKEYQVAPSP EKLMAHGLTL GDVVNALERN NGNVGAGYIE REGEQYLIRA
PGQVRGTQDL GSIIVKQTTD VPIRIRDIAE VGQGKELRTG AATDNGREVV LGTVFMLIGE
NSRKVSQAVD IKMAEINKSL PAGVHAVTVY DRTVLVDKAI ATVKKNLMEG AILVIAILFL
FLGNMRAAVI TAMVIPLSML FTFSGMVSQK VSANLMSLGA LDFGIIVDGA VVIVENCVRR
LAHAQAHHGR ELTLRERFHE VFAASQEARR PLLFGQLIIM IVYLPIFALA GVEGKMFHPM
AFTVVTALLG AMILSITFIP AAVALFIGKK VSETENVVIR TAKRWYEPML NTVMGAKPVV
LTAAAVLVLV CGVVASRMGS EFVPSLNEGD FAVQALRIPG TSLSQSVAMQ TKLESHLKAK
FPEIERVFAR TGTAEIAADP MPPNISDGYV MLKPVDKWPE PRKTRDELLA AVQEEVAKLP
GQNYEFSQPI QLRFNELISG VRSDVAVKLF GDDMDVLNNT ANQIAKVLQG IPGSSEVKVE
QTTGLPMLTI NIDREKATRY GLNIGDIQDT LATAVGGKEA GTLFEGDRRF DIVVRLPEDV
RTDLEAVRRL PIALKGGDGE GARFIPLSEV ASIDSAPGPN QVSRENGKRR IVISANVRGR
DIGTFVGDAQ KALEAVKIPT GYWTVWGGQF ENLQSATQRL QIVVPVSLLL VFVLLFAMFG
NVKDGLLVFT GIPFALTGGI LALWLRDIPL SISAAIGFIA LSGVAVLNGL VMISFIRNLR
DEGRSLDEAI HEGALTRLRP VLMTALVASL GFVPMALATG TGAEVQRPLA TVVIGGILSS
TMLTLLVLPV LYRIVHRKDE EDAQTTETKP SPDAHEDGAI A
//
