ID A0A2U8GTX7_9RHOO Unreviewed; 657 AA.
AC A0A2U8GTX7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Macrolide ABC transporter permease/ATP-binding protein MacB {ECO:0000313|EMBL:AWI76918.1};
GN ORFNames=CEW83_18195 {ECO:0000313|EMBL:AWI76918.1};
OS Parazoarcus communis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Parazoarcus.
OX NCBI_TaxID=41977 {ECO:0000313|EMBL:AWI76918.1, ECO:0000313|Proteomes:UP000244930};
RN [1] {ECO:0000313|EMBL:AWI76918.1, ECO:0000313|Proteomes:UP000244930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSPY31 {ECO:0000313|EMBL:AWI76918.1,
RC ECO:0000313|Proteomes:UP000244930};
RA Woo J.-H., Kim H.-S.;
RT "Azoarcus.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Macrolide
CC exporter (TC 3.A.1.122) family. {ECO:0000256|ARBA:ARBA00038388}.
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DR EMBL; CP022187; AWI76918.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U8GTX7; -.
DR KEGG; acom:CEW83_18195; -.
DR Proteomes; UP000244930; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR017911; MacB-like_ATP-bd.
DR InterPro; IPR025857; MacB_PCD.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR30572:SF14; MACROLIDE EXPORT ATP-BINDING_PERMEASE PROTEIN MACB; 1.
DR PANTHER; PTHR30572; MEMBRANE COMPONENT OF TRANSPORTER-RELATED; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF12704; MacB_PCD; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:AWI76918.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000244930};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..266
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 657 AA; 69756 MW; 67114E90406A5821 CRC64;
MKREAPLAAN DPDARAVQPL IELGGITRSF VNGEVQTRVL HGIDLQIYPG EFVAIMGASG
SGKSTLMNLL GCLDRPSSGT YRFMGQDVAG LDRDELARLR REAFGFVFQS YNLIGGASAR
ENIEVPAIYS GMPPQERHER AEALLATLGL EGRGHHRPNQ LSGGQQQRVS IARALMNGGR
IILADEPTGA LDSRSGEEVM KLLRRLSAEG HTIILITHAP EVAALAQRVI EIRDGRIVSD
PGPVLPAGPE PDFAPHVDRT SSMTDVLEAT RTALRALRSN LFRSVLTLLG IVIGVASVIA
MLAIGDGAKA KVVNQISAMG TNLLNVRPGA PNQRGRDTTA TLVIEDVRAI SDLPNVLAAV
PEQSTGITVR TGNLDHRTSA NATSWDYSFA RKWPVASGTF FSADDETRYA AVAVIGQTVA
EALFPRADPV GEYLLVNNIP FQVVGVMTPK GATSWGADQD DIVFVPFTTG SLRLTGQRHL
RNITVAVDDV GAIDQTQAAV HSLLLARHGV EDFQIRNMAS IIETVSATQN TLTILLGTVA
AISLLVGGIG VMNIMLVSVT ERTREIGIRM ATGARMKNIL QQFLIEALVV SSLGGAIGVG
VGLGSAAIIA LFDTPIEYSL APVVLAFGCA FATGLIFGYL PARKAARLDP VVALASE
//
