ID A0A2U8QS76_9FLAO Unreviewed; 732 AA.
AC A0A2U8QS76;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=recQ {ECO:0000313|EMBL:AWM12998.1};
GN ORFNames=DI487_03365 {ECO:0000313|EMBL:AWM12998.1};
OS Flavobacterium sediminis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2201181 {ECO:0000313|EMBL:AWM12998.1, ECO:0000313|Proteomes:UP000245429};
RN [1] {ECO:0000313|EMBL:AWM12998.1, ECO:0000313|Proteomes:UP000245429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEBiC07310 {ECO:0000313|EMBL:AWM12998.1,
RC ECO:0000313|Proteomes:UP000245429};
RA Baek K.;
RT "Flavobacterium sp. MEBiC07310.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; CP029463; AWM12998.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U8QS76; -.
DR KEGG; fse:DI487_03365; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000245429; Chromosome.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.10.1390; ATP-dependent DNA helicase RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048671; RecQ-1-like_HTH.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF21220; RecQ-1-like_HTH; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AWM12998.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245429}.
FT DOMAIN 29..201
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 222..379
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 535..615
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 732 AA; 82746 MW; 39C9F3B910BF5C74 CRC64;
MKPNEIDLHK ELKKYFGFNQ FKGLQEQVVN SIINGHNTFV IMPTGGGKSL CYQLPALVLD
GTAIVVSPLI ALMKNQVDAI RSLSSEPGVA HVLNSSLTKT EVNQVKSDIT SGVTKLLYVA
PESLTKEEYI QFFNEVNISF VAIDEAHCIS EWGHDFRPEY RNLKNIIRQL GDNVPIIGLT
ATATPKVQED ILKNLDMPDA NVFKASFNRP NLFYEVRPKT KNVEADIIRF IKQHKGKSGV
IYCLSRKKVE DIAQLLQVNG ISAVPYHAGL DAKTRAKHQD MFLMEDVDVV VATIAFGMGI
DKPDVRYVIH HDIPKSLESY YQETGRAGRD GGEGYCLAYY SYKDIEKLEK FMAGKPVAEQ
EIGYALLQEV VAYAETSMSR RKYLLHYFGE EFDEVNGEGA DMDDNVRNPK KKVEAKDQVK
LLLEVIRETK ELFKSKEIIL TLLGKINAVI KSHKIDANPL FGKGSDFDER FWMALIRQVL
VAGYIKKDIE SYGVIKLTDK GKEFIENPIS FMMSEDHEYS ENEEENVVST SKSSGTTDEA
LMNMLKELRK KVAKKLGVPP FVVFQDPSLE DMSLKYPVSI DELSNIHGVG EGKAKKYGKE
FVALIARYVD ENDIIRPDDL VVKSTGTNSA LKLYIIQSVD KKLGLDDIAK AKGLEMEELL
KAMEQIVYSG TKLNISYWVD EILDEDQQEE IHDYFMESES DNIKDALKEF DGDYDTEELR
LMRIKFISEV AN
//
