ID A0A2U8QU01_9FLAO Unreviewed; 1840 AA.
AC A0A2U8QU01;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=DI487_05010 {ECO:0000313|EMBL:AWM13285.1};
OS Flavobacterium sediminis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2201181 {ECO:0000313|EMBL:AWM13285.1, ECO:0000313|Proteomes:UP000245429};
RN [1] {ECO:0000313|EMBL:AWM13285.1, ECO:0000313|Proteomes:UP000245429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MEBiC07310 {ECO:0000313|EMBL:AWM13285.1,
RC ECO:0000313|Proteomes:UP000245429};
RA Baek K.;
RT "Flavobacterium sp. MEBiC07310.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CP029463; AWM13285.1; -; Genomic_DNA.
DR KEGG; fse:DI487_05010; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000245429; Chromosome.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245429}.
FT DOMAIN 976..1118
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1181..1272
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1840 AA; 207216 MW; A330295D46DF32D3 CRC64;
MIKIKTLLKG LFALAFLLII SCSKSNKEFN SDYGLFKEYI QNFSSGLISA HDDIRVVLAF
DIPDWTPETK LDSKLFTINP AVDGKVVALS ANTVAFVPAS PLKNDQEYKV SFHLEKLKDV
PSELETFNFS LKTIKQDFVV NFQDLQSYSK DYFYLNGTIN TSDNFPLEKV TQLIAVQQDG
AKLKIKLDKE LSNAREFKFI VDSIKRFEDD SKIKIAWDGK DFDIKQKGET AIDIPGKNNF
SVLSGEVEDG NTQVLLLNFS DPLKKNQDFD GLVQVESASH LKFATAGNLL KVFFNEPLKG
ELLVEVFQGI QSEDGYKLKQ SFSQKIAFEQ LKPSIRFVKS GTILPSSDNL KINFEAVNLS
AVDVKVYKIY KNNVLQFLQD NELNGNYNLR KVAGPIAKQK IILKKNNLTN YSKWNTYALD
LSKIVNPDPG AIYRVELNFN KKYSLYKCGA VEEENQEETE EQDEEVRRND GGYYYYEDDY
YYDDYNWSER EDPCTNSYYY RKAIATNVAA TNLGVIAKRG ENGSYFFAVN NIVTTEPVPG
ATIDLYNFQQ QKLGTVQTND KGWAEIDLEK YAYFAVVTQN NNTTYVRLDE GQSLSVSNFD
VSGETLQKGL KGYIYGERGV WRPGDTLHIA FMLNDNESKL AGKHPIKFRL SDPKGKLMYQ
TVQKYKENNH YLFDVATKPS DLTGNWEAKI SIGGANFYKS IKIETIKPNR LKIKNSFNDA
QIYGNQPNKG TVQVNWLHGA PAKNLKVEMQ AKFMKEKTTF KGYAPYDFDD DVRKFYTEEV
NVYSGKVDET GLANVTLQPE VNRQSPGKLK VVFQTKAYEN GGDFSTDVVT AHFSPYETYV
GLKSPETNKY GMLETGKKNR FEIITLSEKG KPKAVKNLEV RVYKVDWRWW WNSSNDDLAK
YNSASSTTAY KNFVVNTDAK GKASFQFEVP EEDWGRYLIR VVDEEGGHAT STTQIIDWPI
WSGKSKSGNG ETANMLVFTS DKENYQVGEK AVVSFPSSEG GRALLSFENG SKVVQTLWAN
TTKGETKVEV EITPEMAPNV YIHISLLKPH ASTQNDSPIR MYGILPIEVI DKNTVLKPQI
EMAEVLRPEK EATITVSEQS GREMTYTIAI VDEGLLDLTR FKTPNAWDKF YAKQALGVRT
WDIYDDVIGA YGGKINQIFS IGGDEDLGGS KAKKANRFKP VIIYKGPFKL EKGQKATHHF
TMPNYVGSVR AMVVAGNAQE DAYGSTEKTV PVKNPLMVLA SMPRKISPTE KITLPITVFA
MENKVKNVSV QIKTNSFLSL QGASQKSVSF ESPDEKMVYF DLEATDKIGI AKLEVIATSG
SQKATYEVEL DVENPNPLTN DFVDVVLEPN ESKEINWSTF GVAGTNKAGV EVSSFPTIDF
GRRLQYLIQY PHGCVEQTTS SVFPQLYLAD VVAVSDSQKQ KIQQNINEGI QRLGRFQLAS
GGLSYWQGNS TANDWGTSYA GQFMMEAEKK GFVLPIGFKQ KWIAFQQKQA KQWRYNTDFH
NDFAQAYRLY TLAVAGQADL ASMNRLRETV GISTDSKLRL AAAYALAGQK ATAQKIMSSI
NWNAVNDENR YYYYYYGSED RNRAMLLETY LLVDDKAKAF QTANILAKHL SGRYYMSTQT
TAYSLYAMSK FAIKNGSKGV NCNVTFNGKT EKLTTTKSVL EKELVVNQGE YSVSLKNTGN
ATLYVRVLNS GVLPMGQERE MQKNLSAQIA YKTRNGEAVN LSNVKQGTEL VAQVTVKNTA
TEAIQNVALA QIFPSGFEIV NSRFTDFGSF AENKADYIDI RDDRTQFYFG LKRGESKTFT
VLLNASYLGT YYLPGIQCEA MYDDNYVFRN KGQWITIVNE
//
