ID A0A2U9AX14_SCOMX Unreviewed; 1410 AA.
AC A0A2U9AX14;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=mitogen-activated protein kinase kinase kinase {ECO:0000256|ARBA:ARBA00012406};
DE EC=2.7.11.25 {ECO:0000256|ARBA:ARBA00012406};
GN ORFNames=SMAX5B_002535 {ECO:0000313|EMBL:AWO96176.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWO96176.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWO96176.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000478};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.25; Evidence={ECO:0000256|ARBA:ARBA00000106};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. MAP kinase kinase kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00006529}.
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DR EMBL; CP026243; AWO96176.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000005832; -.
DR Proteomes; UP000246464; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046872; DRHyd-ASK.
DR InterPro; IPR046873; HisK-N-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF391; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF20309; DRHyd-ASK; 1.
DR Pfam; PF20302; HisK-N-like; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000313|EMBL:AWO96176.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|EMBL:AWO96176.1}.
FT DOMAIN 718..976
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1280..1329
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 44..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 747
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1410 AA; 158221 MW; 864ED2AA73593244 CRC64;
MSCESRGPVA FGFSGRSRTG GRVEWRGATR NVVRGESGGG DAPGELTTTK NQEPNATETT
RSSPRTCAEL RPRTTGEQTM FTTERRRMSR RMSLHELKRR DPVRVSAGSF WQDSDAVELG
AGGAGRQLVS PRSRTRDVSV AYIVNEDASV PQTEENLSLK CLKEACADAH AAFKSVSFER
ISQGTTDILD CFYNAGKYVA VVEMSDSFCQ PSLFYHLGVR ESFSMTNNII LYCYKPDGDL
QAIKEQCGSY TFIPYVVSPQ GKVFACDASM MTGIKELMQP SFQLEPLLTP LVESLVHLLS
NVHIQSSEYF RESIRHEIRM ARERFSGQAL SEELGHIQKR LDSVELLTPD IVMNLLLSYR
DIQDYDAIIN LVETLNHLPM CLVARHPNIQ FHYIFALNRR NRPGDRAKAL EAILPIVESG
GKVASDVYCL CGRIYKDIFM SSGFTDQSNR DQACYWYGKA FETEPTLHSG INNVVLLMAA
GHEFDTSIEL RKIGVTLSTL LGRKGSLEKM RDYWDVGFYL GANILVNEHR KVIEASEKLY
RLKAPIWYVA SIMETYILYR QFSKPPVVRY PKQDTVDFWM ELLLQTCKPT VSTDRCPVLV
LEPSKVLQPA IVCVSEEDES RTVQLKHVTP LKKGLHQWTF PASAIRGVSA SKIDERSCFL
YVHYNSDDFQ LCFPSELHCT GFCELVNSLL QQAEDSAIQD LDRQTEGILE YIYETSENCD
KVVLGKGTYG VVYAGRDLSN QVRIAIKEIP EKDSTYSQPL HEEIALHKRL KHRNIVQYLG
SVSQDGFIKI FMEEVPGGSL SSLLRSKWGP LKDNEATIIF YTKQILEGLK YLHDNQIVHR
DIKGDNVLIN TYSGVLKISD FGTSKRLAGI NPCTETFAGT LQYMAPEIID QGPRGYGKPA
DIWSLGCTII EMATGKPPFH ELGSPQAAMF KVGMFKIHPK VPECMSDEAK GFIMNSFVPN
PDDRATAAEL LMDAFIRSSP RKRAKAPQES ELQSPLSTDY HRSLSVPISI LVEDTDSYSG
SIDLSCSLDL RRPHYALRVH EVSESPPSTG GFLPIPEDSP SDMSSPASTE ENIGLFMLRK
DSERRATLHR VLTDYNGHVI SNIQESVPQY GKGSSLTADH ITKLIGCLRD NIHSPDRKQL
TSDLLDLRAT LLAATVPLNS LQTVLFSFQD AVKKVLKQQQ VKPHWMFALD NLLRQAVQDA
ISVLLPELKL QLQSSFEIED STPEEQSADP STPVVYVPDQ LGAPADLQPS SPTCEITPTA
DPYSPTDLVL NTSCPHSEKL RELRLETKRL LGQLSEKETE YQELLKTSVQ RKQEQIDALR
KTAVTEEKKQ NPEVKALVRW LKSVPVDQDT IDKLLTHEFT LDCLLHMASR DDLMYCGIKG
GTLCRIWEAI AVRRKTQLSK HDEDSEDTLL
//
