ID A0A2U9AZP1_SCOMX Unreviewed; 915 AA.
AC A0A2U9AZP1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Nucleotide-binding oligomerization domain 1 protein {ECO:0000313|EMBL:AWO97153.1};
GN ORFNames=SMAX5B_013723 {ECO:0000313|EMBL:AWO97153.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWO97153.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWO97153.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR EMBL; CP026243; AWO97153.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U9AZP1; -.
DR Proteomes; UP000246464; Chromosome 1.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08324; CARD_NOD1_CARD4; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF18; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 5..77
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 185..325
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 915 AA; 103496 MW; 53219D4F6BAF816C CRC64;
MDRAEEARCL NILTCHRELL VSKLRSVQCV LDNLLTCGFL CEEDVEIVQR TATKTDQVRK
ILELVQCKGE VACEYFIFIL YNVCDAYIDL QPWLTEINFN PSSHMKVMSV VNTDPISRYR
EKLRHEMRRD TCFIMSYGQQ EETRLEDLYT DTLMELMNDR NESLGFVESL DQLLGDHAAF
NPQGEIIYVM GDAGVGKSIL LQKLQNLWSK QELRTDAIFF FKFRCRMFNL FKDTEEISLR
DLLFKYNCRP DLDPDDEVFD YILRFPEKVI FTFDGYDEIQ EDLDLKNAPE VVCPEVRAHP
LQLLVSLLCG KLLKSSQKVL TARTGIELQS RVIRKKVALL GFSSSHLKTY IDLHFKEQEH
RKLVSVQLDA SPHLCGLCST PLFCWIVFRS FRHLHAMHDR FTLPDTCITL TDIFLLLSEV
FFSRSTSRAP SLLKKSTRCS SETFKAGLRP LAAFAKLALQ GMERGSFICN PEEVTACGLR
EEDLPLGFLK PFSECDASGN PANFEFLHIT LQAFLAAFAL VLDEQAAADS ILKFFTECSR
KRERSCLPFD LCITGSSKQS QKKPFATTDH LQFTNLFLCG LLSKAHTGLL EHLVSPRLLK
KKRALLKSYL STSIRSHLHG LPHYDGEEGR KVHVLPNFLW MLRCIFETGS KDIAHMTAKG
ITASFIKLGY CNVYSGDCTA LNFVLQHRRG LLGVDMDNNN ISDYGVKQLR PSFCKMTVVR
LCVNHLSDSS IEVLAEELCK HKVVEVLGLY NNHITDVGAK LVAQIIEECP KLRILKIGKN
KITGVGGRYL ARAIQTSTSI FDVGMWGNSI GDEGAEAFAE ALRHHPQLTN LSLSANGITS
KGGKCLTDAL KENSTLRIFW LVQNELTDDA APHLAELVKA NTGLKHLWLI NNQLTVHGVK
HLAEALAHNT ALKEI
//
