ID A0A2U9B7M8_SCOMX Unreviewed; 2789 AA.
AC A0A2U9B7M8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=AF-4 multi-domain protein {ECO:0000313|EMBL:AWO99970.1};
GN ORFNames=SMAX5B_019363 {ECO:0000313|EMBL:AWO99970.1};
OS Scophthalmus maximus (Turbot) (Psetta maxima).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC Scophthalmus.
OX NCBI_TaxID=52904 {ECO:0000313|EMBL:AWO99970.1, ECO:0000313|Proteomes:UP000246464};
RN [1] {ECO:0000313|EMBL:AWO99970.1, ECO:0000313|Proteomes:UP000246464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Martinez P.;
RT "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT evaluation of genetic and physical mapping variation across individuals.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR EMBL; CP026246; AWO99970.1; -; Genomic_DNA.
DR STRING; 52904.ENSSMAP00000007778; -.
DR Proteomes; UP000246464; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR Gene3D; 6.10.250.3120; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR InterPro; IPR014800; ASD1_dom.
DR InterPro; IPR014799; ASD2_dom.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF15; AF4_FMR2 FAMILY MEMBER 4; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
DR Pfam; PF08688; ASD1; 1.
DR Pfam; PF08687; ASD2; 1.
DR PROSITE; PS51306; ASD1; 1.
DR PROSITE; PS51307; ASD2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00637};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000246464}.
FT DOMAIN 1813..1938
FT /note="ASD1"
FT /evidence="ECO:0000259|PROSITE:PS51306"
FT DOMAIN 2520..2788
FT /note="ASD2"
FT /evidence="ECO:0000259|PROSITE:PS51307"
FT REGION 1..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1355..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1686..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1747..1794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1853..1918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1985..2077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2092..2172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2190..2230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2243..2415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2441..2518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2611..2638
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1560..1576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1686..1702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1747..1775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1875..1900
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1987..2004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2092..2120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2155..2172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2265..2319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2335..2392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2463..2477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2478..2518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2789 AA; 307416 MW; A1D6E2303FDE106E CRC64;
MNREDRNVLR MKERERRNQE IQQGGGEAFP ANSPLFPEPY KVSSKEDKLS SRIQSMLGNY
DEMKEPIGDT LPKLGGKPSN SSSSSEEKSG PPLFGGDQRG VGTGGSSQSS KWTPVGPAGG
TSSQSQKRSG LQGGHGSQRN TGGSSSSSSS SQRHGEVREK KSSKHSGGSE HSKSHTSSPA
KGSLSSSSSN SHSRSSLSAE QHHSKERYRS KSPRDREANW DSPSRVHTSF TSGQHSSQAF
PPSLMSKPGS MLQKPTAYVR PMDGQETAEP KSSQAESYSG QSHSSTMGEM KSNGKASLSK
LKIPSQPVEG SGDANCVDEI LKEMTQSWPP PLTAIHTPCK TEPSKFPFPT KESHPFPSGH
KRGSSSKSSS SHQSKACDDQ PTLEDDLKLS SSEDSDVEQD SAKNASRNTS ASNNSEGAEQ
SRDDSSSHSG SESSSGSDSE SESSTTDSEA NEPPRPASPE PEQPMANKWQ LDNWFKKAKQ
FSPASPVDNN VPTKCKKEGR DNSSGRSYGS QGGGSKDSAT PTPSRDLRAA QKGAEGGRGR
QKSPAQSEGG ANPRIRVGKK QPKKSEKPPV VEEPKGGLRV ESEPAPEIPP HRPKAATKGS
RKPNIKKEPK SSPRPTAAAV TNTVDKRKPK APTKTSQKSR EFVDTDSSSS DSEGNESIPS
SSQTPKYTES IRTPVCVFSP MEEKELLSPL SDPEERYPAR PPQQQVLLVK IDLSLLSRIP
GRPYKEPVEI KVERDDSLDR DGKDFSKQSS EKSSSKAKRK HKNDEEGTKP ESKRCKLEEK
SLSHHKNSSK ESKRSLEKKE EPVPSPSMSG LQRTPKADHP SRKRTVSQSS TSLSSGTGSG
KEGGHSTKGS STSKHRKGED KGRSTRDGKE KSSKGCDNQL AVPPLSSDGS KSQRSKLVFE
DRVHSADHYL QEAKKLKHNA DALLDRFEKA VYYLDAVVSF IECGNALEKS AQEAKSPFPM
YAETVELIKY TMKLKSYMAP DATSADKRLA VLCLRCQSLL YLRLFKLRKD SALKYSKTLT
EHLKNSLSNT QAPSPGMGNK AAGMPSPVSP KLSPGTAGGY SSVTSSSSAS SSVTIPQRIH
QMAASYVQVT SNFLYATEVW DQAEQLSKEQ KDFFLELDKA MGPLIFNTSS MTELQGVFSV
HKAHTCIGAH TRTTHTQTPP FLSRHPPRSS MDSYNFHFER MSNVDLHSLS LPVSRLSPAK
SNSSIVDQLA HHQHGKGDSA YSSFSGGSTA PDYPSPFVPD DLHSSAFSHY ADLKYVKSIY
HPTQVVQSDS KTMDQLFRSV EAISQHYRNN TSTNVNHHNH NGNDSFHNNK NNKVLSKQEV
SSGSPSKGSY PPVHPPPVPA RLDSFIATKN LENSRVHHHQ GTEFQPPQPQ PQQQPRPYNR
LHSQHHGLNA RNPEKANPDT ANSSLNSDPV FSVWRGSQPQ AQQAPVHRPH LQSHDQTRVP
LNPEYPFILD NKADSEQQKS KNLPSGSPPR GTSQSDYLKP RQLSSSGGCN GDHHNKSSGS
SSNVESQRKR AHSAHDWLGS ETSRAASPWN SGQSFINSSI QHKGQFYFVT GLCKLSDSGM
RTNSSSVCGS DTGSESSTVL EKHRIREKER SHSTMDSLFR PLQESSRTSS GTIPGEREVF
TSVSQGKDLS SRSQDQENHR PSFLLTQSSR SFDSLEEINM IQSREIGRHT ANNPIFYCGP
DRNCPPHSAT QTKEAASLIS NEQPNHKREE QAKREKRQPL GDVASERINK ETTPLLYHLT
EANRAALQPR KEAESSMKGK EAILHKTDHG DVSGNDNKRP PQGDMSKNDR GDGISVACNT
LDDSFKKYYK EKLKDAQSKV LRETSFKRRD LQLSWPHRIR QKPELRPSVI HSFSLSQDSE
MSTDTLTPSV TSEETERGSI KEEVSENQNE TDKETEKENG RPSNVAQPQV ARVGGRKRLT
LEQKKMCYSE PEKLNQLGST PSHSACRSYG NESDNLFASE CDGEECVQQG EPGLVAARRK
MFETRGRALS ASSTSKTNLK QQQHKALVEY MERKTGQKVA EPQQPAPQLP PSPRQRHSLG
EKPFDWGPRP QSGNHEGKNT KKKLHRPHSA GRILDSSTSS IRYAQFFSAQ SCSGQFADQS
NQPRWRESQG PYQGKSASVE SLLDQPEPPS FYRNRSISTP QAYQAHDDER DPSPVNTMET
CSPQTTTTEN SWVKRVSEGK PYVRVVAQRG KSMEELGASK LTRPSALSKS SEQLDQLWRR
STGPGGAEVE KRSFSFITEV REAQGLERGR NKQYLTEQAG EEPDVVGQKN TQGQIQNQTQ
KTPPLKQNSE PGEDATVGTR NSSRSTSPAS RSFSRARVRS GSPGSHDPVT DEVRSSRPPS
ETSSNQPSPR VTETNERVIK STSSTPVQTK LPCESRLCFS SVRTSPSATG TEREQFVDEP
KSDTPLPDSN HEVSLSCGVT TDPSLWILPL EEVIKEEVQN SPLTDGVFDD ESPCPAPRPQ
TSETPVSPRA SVSEADVTQQ AEEEKSPEME DEKSAENQEL EEKAAPEESP EELGGRPQWE
ELVEAVVKAD QSLARTLYPL TDRKTALMLM EQLLSEDTLL MEEHYKKKQE QRGDAESAEV
VKGAEAPQCL SAAEESLTPQ SADPQSKVDV TEKKQLLVSR IEERLRSLEE TRGALQTEVE
ENAGRGKALE ALVRERCAPV ELERYNLFIG DLQRVVSLLL CLSARLARVQ NALSTVDQHT
DAEEKQSLDS RHRLLCKQRE DAKDLKDNLD RRENLVSTFL SRQLSAEQLR DYRRFVQTQA
SLLIRQKDLE EKQRLGEEQL EALSHSLRL
//
