ID   A0A2U9B9X0_SCOMX        Unreviewed;      1003 AA.
AC   A0A2U9B9X0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Cytochrome P450 {ECO:0000313|EMBL:AWP00755.1};
GN   ORFNames=SMAX5B_013611 {ECO:0000313|EMBL:AWP00755.1};
OS   Scophthalmus maximus (Turbot) (Psetta maxima).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Scophthalmidae;
OC   Scophthalmus.
OX   NCBI_TaxID=52904 {ECO:0000313|EMBL:AWP00755.1, ECO:0000313|Proteomes:UP000246464};
RN   [1] {ECO:0000313|EMBL:AWP00755.1, ECO:0000313|Proteomes:UP000246464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Martinez P.;
RT   "Integrating genomic resources of turbot (Scophthalmus maximus) in depth
RT   evaluation of genetic and physical mapping variation across individuals.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617}.
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DR   EMBL; CP026246; AWP00755.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U9B9X0; -.
DR   STRING; 52904.ENSSMAP00000019616; -.
DR   Proteomes; UP000246464; Chromosome 4.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   InterPro; IPR019336; GPR180/TMEM145_TM.
DR   PANTHER; PTHR24291:SF112; CYTOCHROME P450 4F2; 1.
DR   PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR   Pfam; PF10192; GpcrRhopsn4; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000246464};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1003
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015933601"
FT   TRANSMEM        166..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        279..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        351..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        382..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        486..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          136..400
FT                   /note="GPR180/TMEM145 transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF10192"
SQ   SEQUENCE   1003 AA;  113275 MW;  1641DB58BDCBD64A CRC64;
     MAHVLAALVA AVLLGSEACG KTVTGLFRSD AARQQSGQFI TKFMYQGDNG LLVCRLENTA
     LATEKESRLL LYHDVDSDLD NLSCTERLAR AYLSIPLGQE EHNQTMPRQS SPTAWRALYA
     DRYTCQESAV IPSHADLSFT VLLFNADSAG NPLEHFSAEE AGLHSFYFLL LLAYFIACCI
     YIQPLHQALR KGGPMHTVFK VLTTALALQG CSALCNYIHL SRYSRDGVGI PLVGSLAEFW
     DMVSQVSMLY MILSLCVGWT LSRGRKPQAR PLQWEHSPAS TAVAVGGVVT QGALLLWEQY
     SESGGEHHSY HAQRSLAGVL LMALRVFLAL LLASVLYQII ATERSTLKRD FYLTFAKGCF
     LWFLCHPVLV LMSVIFNEHQ RGKVVTIGVI LCQSISMVAL RSLRLLCSTM SLTLRRNDTI
     RRMKRSTCTL DPFPTALTPK RLKLRGGQWE KSCDMQQRHV VLTSSWMSLL QGVLSWVLSW
     AGLCQIMAVV GIGLVALVAV WMARLLARHA WYTHRLSCFC RPHADSWLMG HMGQMQSTEE
     GLLQVDELVQ TYKHSCSWFL GPFYHFVRVF HPDYVKPLLM ASASITVKDE LIYGHLRPWL
     GRSLLLSNGE EWLRRRRLLT PVFHFDILKS YVATFNTSTD TMHGKWRCLV AEGRANMEMF
     DHVTLMTLDS LLKCVFSYNS NCQELTSEYV SAIVELSDLI IDRRLKILHH WDWFYWKTQQ
     GKKFKKALSV VHGFTSEVVQ KRRTLINQQT GAETDFTTAP QRRKDFLDLI LQSKDDDGLG
     LTDEEIQAEA NTFMFAGHDT TASAICWTLY NLARHAHFQE KCRQEVMDLM QGRDRHAIEW
     EDLSNLTFTT MCIRESLRLH SPVQAVTRQY TQDMALPGGR TVPEGAICLV SIYGTHHNPT
     VWTNPNEFDP LRFDPSNTKK RPSHAFIPFS SGPRNCIGQK FALAELRVVV ALTLLRFRLT
     LGVNPELGTS SGGIRRVPQL VLRAEGGLWL RLEPLTTPGV EEP
//